Table 4.
Summary of the Plasma Pharmacokinetic Parameters of Baricitinib on Day 10 Following Multiple Oral Doses of 2 to 10 mg in Healthy Chinese Subjects
| Arithmetic Mean (SD) | |||
|---|---|---|---|
| 2‐mg Baricitinib | 4‐mg Baricitinib | 10‐mg Baricitinib | |
| PK Parameters | (N = 8) | (N = 8) | (N = 8) |
| AUCτ,ss, ng · h/mL | 146 (17.0) | 268 (48.2) | 778 (101.0) |
| Cmax,ss, ng/mL | 28.6 (6.95) | 49.6 (14.4) | 138.0 (22.8) |
| Tmax,ss, a h | 0.50 (0.50‐1.50) | 1.00 (0.50‐1.50) | 1.00 (0.50‐1.50) |
| t½, h | 5.68 (0.63) | 7.55 (1.88) | 7.39 (2.48) |
| CL/F, L/h | 13.9 (1.66) | 15.3 (2.64) | 13.1 (1.95) |
| RA | 1.11 (0.11) | 1.06 (0.20) | 1.05 (0.07) |
AUCτ,ss, area under the plasma concentration–time curve during 1 dosing interval at steady state; CI, confidence interval; CL/F, apparent clearance; Cmax,ss, maximum observed drug concentration at steady state; CV, coefficient of variation; PK, pharmacokinetics; RA, accumulation ratio; t½, apparent terminal half‐life; tmax,ss, time to maximum concentration at steady state.
Data displayed are arithmetic mean (SD), unless otherwise stated.
a
Median (range).