TABLE 5.

Impact of different values of nonadherence in comparative effectiveness research

	Truth		Observed data
Paroxetine use versus nonusers	Drug P1	Drug P0	Drug P1	Drug P0
Y = 1	150	9900	217	9833
Y = 0	850	89 100	1450	88 500
Total	1000	99 000	1667	98 333
Risk	0.15	0.10	0.13	0.10
RR	1.5		1.4
Escitalopram versus nonusers	Drug E1	Drug E0	Drug E1	Drug E0
Y = 1	75	9950	87.5	9937.5
Y = 0	425	89 550	537.5	89437.5
Total	500	99 500	625	99 375
Risk	0.15	0.10	0.14	0.10
RR	1.5		1.8
Escitalopram versus paroxetine	Drug P1	Drug E1	Drug P1	Drug E1
Y = 1	150	75	217	87.5
Y = 0	850	425	145	537.5
Total	1000	500	1667	625
Risk	0.15	0.15	0.13	0.14
RRE−P	1.0		1.08

Note: Values used: baseline risk: 0.1; RR: paroxetine 1.5, escitalopram 1.5; exposure prevalence: paroxetine 0.01, escitalopram 0.005; data capture: paroxetine 1.0, escitalopram 1.0; adherence: paroxetine 0.6, escitalopram 0.8.

Abbreviations: P1: exposed to paroxetine; E1 exposed to escitalopram; P0 and E0 nonexposed to paroxetine or escitalopram; Y = outcome.