FIGURE 3.

Diagnostic accuracy. ROC curves and corresponding AUC for CIN3+ detection for (A) single marker classifiers ASCL1, LHX8, ST6GALNAC5, GHSR, ZIC1 and SST and (B) bi‐marker panel ASCL1/LHX8 (black line), including point estimates of cytology (red circle), HPV16/18 genotyping (green circle) and bi‐marker panel ASCL1/LHX8 with the predefined threshold calibrated at 70% clinical specificity (yellow circle). For comparison, the cross‐validated ROC curve and corresponding AUC, as obtained in the hrHPV‐positive training series, are projected (grey line). ¹⁰ AUC, area under the curve; CIN, cervical intraepithelial neoplasia; ROC, receiver operating characteristic [Color figure can be viewed at wileyonlinelibrary.com]