TABLE 2.
Patients' demographics and disease characteristics at evaluation
| Population group | ||||||||
|---|---|---|---|---|---|---|---|---|
| <10 years (N = 243) | 10–15 years (N = 136) | ≥16 years (N = 589) | Overall (N = 968) | |||||
| Male (N = 147) | Female (N = 96) | Male (N = 80) | Female (N = 56) | Male (N = 298) | Female (N = 291) | |||
| Age, years | Mean (SD) | 5.68 (2.16) | 5.38 (2.11) | 12.82 (1.65) | 12.50 (1.51) | 38.46 (13.69) | 36.63 (11.86) | 26.00 (17.69) |
| Median (IQR) | 5.38 (3.92, 7.36) | 4.94 (3.76, 6.90) | 12.90 (11.81, 13.89) | 12.12 (11.57, 13.55) | 38.50 (27.00, 47.00) | 36.00 (27.00, 45.00) | 24.00 (9.92, 40.00) | |
| Height, cm | Mean (SD) | 112.10 (13.34) | 109.38 (14.26) | 151.90 (14.49) | 150.80 (9.35) | 168.49 (8.51) | 156.78 (7.31) | 145.86 (25.48) |
| Median (IQR) | 111.00 (102.00, 122.00) | 107.75 (99.00, 119.00) | 153.50 (141.00, 162.25) | 152.25 (144.75, 157.00) | 168.00 (163.00, 174.00) | 157.00 (152.00, 161.00) | 155.00 (126.00, 165.00) | |
| Height z‐score | Mean (SD) | −0.39 (0.96) | −0.39 (1.00) | −0.58 (1.46) | −0.30 (1.01) | −1.27 (1.37) | −0.99 (1.25) | −0.81 (1.27) |
| Median (IQR) | −0.34 (−0.87, 0.16) | −0.49 (−0.95, 0.39) | −0.36 (−1.51, 0.46) | −0.21 (−0.97, 0.19) | −1.33 (−2.18, −0.40) | −0.96 (−1.81, −0.27) | −0.78 (−1.59, –0.07) | |
| Weight, kg | Mean (SD) | 20.68 (6.71) | 19.52 (7.21) | 46.35 (14.33) | 44.74 (10.11) | 72.73 (14.20) | 55.59 (8.96) | 47.49 (23.20) |
| Median (IQR) | 19.00 (16.00, 24.00) | 18.00 (14.60, 22.00) | 45.60 (36.00, 54.50) | 46.00 (38.00, 52.00) | 70.00 (63.00, 80.00) | 54.00 (49.00, 61.00) | 50.00 (25.00, 64.00) | |
| Weight z‐score | Mean (SD) | −0.48 (1.04) | −0.56 (1.04) | −0.49 (1.20) | −0.35 (0.92) | 0.12 (1.26) | −0.17 (1.05) | −0.24 (1.14) |
| Median (IQR) | −0.39 (−1.25, 0.18) | −0.54 (−1.18, 0.24) | −0.46 (−1.32, 0.29) | −0.40 (−1.06, 0.24) | 0.10 (−0.69, 0.96) | −0.24 (−0.94, 0.58) | −0.24 (−0.99, –0.52) | |
| BMI | Mean (SD) | 16.11 (2.25) | 15.86 (2.21) | 19.44 (3.66) | 19.53 (3.17) | 25.70 (4.50) | 22.82 (4.09) | 20.90 (5.30) |
| Median (IQR) | 15.86 (14.65, 16.96) | 15.51 (14.40, 16.62) | 18.69 (16.88, 21.23) | 19.35 (16.94, 21.56) | 25.02 (22.84, 28.08) | 21.99 (20.17, 24.56) | 20.31 (16.62, 24.22) | |
| BMI z‐score | Mean (SD) | −0.36 (1.20) | −0.36 (1.04) | −0.36 (1.02) | −0.27 (1.01) | 0.85 (1.12) | 0.34 (1.10) | 0.15 (1.22) |
| Median (IQR) | −0.24 (−1.10, 0.46) | −0.24 (−1.03, 0.36) | −0.50 (−1.04, 0.31) | −0.29 (−1.04, 0.46) | 0.91 (0.23, 1.62) | 0.32 (−0.37, 1.07) | 0.22 (−0.69, –0.96) | |
| Inheritance, n (%) | De novo | 65 (44.2) | 43 (44.8) | 27 (34) | 20 (36) | 83 (27.9) | 80 (27.5) | 318 (32.9) |
| Maternal | 31 (21.1) | 23 (24) | 26 (33) | 22 (39) | 89 (29.9) | 79 (27.1) | 270 (27.9) | |
| Paternal | 48 (32.7) | 25 (26) | 23 (29) | 12 (21) | 88 (29.5) | 98 (33.7) | 294 (30.4) | |
| Not available | 3 (2) | 5 (5.2) | 4 (5) | 2 (4) | 38 (12.8) | 34 (11.7) | 86 (8.9) | |
| Malignant Degeneration, n (%) | Presence of SPC | 0 (0) | 1 (1) | 0 (0) | 0 (0) | 38 (12.8) | 17 (5.8) | 56 (5.8) |
| Absence of SPC | 147 (100) | 95 (99) | 80 (100) | 56 (100) | 260 (87.2) | 274 (94.2) | 912 (94.2) | |
Abbreviations: BMI, body mass index; IQR, interquartile range, 25°–75°; SD, standard deviation; SPC, secondary peripheral chondrosarcoma.