TABLE 2.
Top 50 differentially induced genes through the observed timepoints
| Gene symbol | Gene name | sFPKM | Expression ratio compared to Unt | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Unt | 1 hr | 6 hr | 1 d | 3 d | 6 d | 12 d | |||
| Nppb | Natriuretic peptide B | 0.2 | 0.1 | 44.4 | 152.6 | 15.0 | 0.8 | 7.6 | 1017.1 |
| Tnn | Tenascin N | 0.3 | 0.4 | 1.1 | 7.9 | 238.1 | 114.9 | 98.6 | 882.0 |
| Krt17 | Keratin 17 | 10.1 | 10.1 | 1577.4 | 8747.5 | 2017.5 | 116.8 | 856.4 | 868.7 |
| Il6 | Interleukin 6 | 0.1 | 55.0 | 93.8 | 13.3 | 7.4 | 3.0 | 1.7 | 781.8 |
| Cxcl2 | C‐X‐C motif chemokine ligand 2 | 0.2 | 105.3 | 63.9 | 60.4 | 11.6 | 2.9 | 9.7 | 657.9 |
| Cxcl1 | C‐X‐C motif chemokine ligand 1 | 0.9 | 468.4 | 80.0 | 33.7 | 7.0 | 2.6 | 5.0 | 514.8 |
| Stfa2l1 | Stefin A2‐like 1 | 0.2 | 0.6 | 73.5 | 61.2 | 14.8 | 0.7 | 3.3 | 408.3 |
| Cxcl3 | C‐X‐C motif chemokine ligand 3 | 0.1 | 1.1 | 41.5 | 28.7 | 7.3 | 1.6 | 5.8 | 345.8 |
| S100a9 | S100 calcium‐binding protein A9 | 20.9 | 470.6 | 2417.2 | 5075.9 | 1354.9 | 133.6 | 591.2 | 242.4 |
| Slpi | Secretory leukocyte peptidase inhibitor | 4.0 | 20.8 | 742.6 | 817.6 | 574.7 | 181.0 | 348.3 | 202.4 |
| Klk6 | Kallikrein related‐peptidase 6 | 0.3 | 0.1 | 2.9 | 34.2 | 47.2 | 2.7 | 23.4 | 188.8 |
| Sh2d5 | SH2 domain containing 5 | 0.1 | 0.1 | 10.8 | 19.3 | 2.3 | 0.3 | 0.9 | 175.5 |
| Ptx3 | Pentraxin 3 | 1.1 | 12.2 | 184.4 | 83.3 | 25.6 | 7.7 | 7.9 | 170.7 |
| Reg3g | Regenerating family member 3 gamma | 0.1 | 0.1 | 22.8 | 3.5 | 0.9 | 0.2 | 0.2 | 163.0 |
| S100a8 | S100 calcium‐binding protein A8 | 23.9 | 129.9 | 1126.9 | 3585.5 | 996.8 | 117.8 | 576.5 | 150.2 |
| Stfa2l2 | Stefin A2‐like 2 | 10.7 | 18.5 | 363.3 | 1568.6 | 319.1 | 37.5 | 61.0 | 146.3 |
| Gip | Gastric inhibitory polypeptide | 0.1 | 0.1 | 0.9 | 17.5 | 9.0 | 0.8 | 1.2 | 145.4 |
| Stfa2 | Stefin A2 | 42.2 | 57.7 | 1177.8 | 5359.0 | 1416.7 | 193.1 | 293.8 | 127.1 |
| Stfa3 | Stefin A3 | 36.3 | 24.4 | 340.5 | 4522.3 | 3008.5 | 1512.6 | 738.5 | 124.5 |
| Ifnk | Interferon kappa | 0.1 | 0.1 | 7.3 | 15.7 | 3.0 | 2.1 | 0.8 | 121.0 |
| Defb4 | Defensin beta 4 | 1.3 | 2.4 | 101.5 | 138.2 | 77.5 | 25.0 | 52.0 | 110.5 |
| Nat8l | N‐acetyltransferase 8‐like | 0.4 | 0.3 | 14.6 | 40.3 | 6.7 | 1.3 | 2.1 | 108.8 |
| Il24 | Interleukin 24 | 1.8 | 3.0 | 55.7 | 167.8 | 10.2 | 2.6 | 7.7 | 91.7 |
| Ear1 | Eosinophil‐associated, ribonuclease A family, member 1 | 0.1 | 0.1 | 0.2 | 12.2 | 5.1 | 0.5 | 1.5 | 87.1 |
| Areg | Amphiregulin | 1.1 | 1.7 | 32.2 | 94.5 | 8.1 | 1.4 | 8.9 | 85.9 |
| Mmp12 | Matrix metallopeptidase 12 | 0.3 | 0.2 | 7.8 | 24.2 | 22.7 | 16.4 | 23.4 | 75.5 |
| Slc6a14 | Solute carrier family 6 member 14 | 0.1 | 0.2 | 10.5 | 9.5 | 1.9 | 0.4 | 3.1 | 75.1 |
| Il1b | Interleukin 1 beta | 2.0 | 68.1 | 141.7 | 62.3 | 25.5 | 10.6 | 24.3 | 69.8 |
| Tarm1 | T cell‐interacting, activating receptor on myeloid cells 1 | 0.1 | 0.8 | 7.7 | 1.2 | 0.4 | 0.2 | 0.2 | 64.4 |
| Fcar | Fc fragment of iga receptor | 0.1 | 2.1 | 8.2 | 1.8 | 0.4 | 0.1 | 0.3 | 62.8 |
| Hmox1 | Heme oxygenase 1 | 17.9 | 20.1 | 1125.7 | 346.3 | 354.4 | 93.4 | 110.5 | 62.7 |
| Mcemp1 | Mast cell‐expressed membrane protein 1 | 0.8 | 9.7 | 45.0 | 10.9 | 4.0 | 1.2 | 2.4 | 60.0 |
| Ccl12 | C‐C motif chemokine ligand 12 | 0.2 | 0.2 | 11.7 | 5.7 | 9.0 | 4.9 | 3.0 | 58.7 |
| Fcrl2 | Fc receptor‐like 2 | 1.3 | 1.3 | 0.6 | 11.4 | 73.5 | 31.2 | 26.9 | 57.4 |
| Fosb | Fosb proto‐oncogene, AP‐1 transcription factor subunit | 4.3 | 245.8 | 2.6 | 1.5 | 3.0 | 5.5 | 4.3 | 56.8 |
| Osm | Oncostatin M | 0.4 | 9.4 | 23.4 | 4.4 | 3.2 | 1.1 | 2.0 | 54.4 |
| Sirpb2l1 | Signal‐regulatory protein beta 2‐like 1 | 0.4 | 1.8 | 19.8 | 6.6 | 1.9 | 0.4 | 1.1 | 53.5 |
| Cxcl6 | C‐X‐C motif chemokine ligand 6 | 0.1 | 0.1 | 5.8 | 3.1 | 1.3 | 0.4 | 0.7 | 53.0 |
| Fcnb | Ficolin B | 4.6 | 8.8 | 231.0 | 29.7 | 21.2 | 5.2 | 4.8 | 50.0 |
| Oscar | Osteoclast associated, immunoglobulin‐like receptor | 0.3 | 1.8 | 16.4 | 5.0 | 3.3 | 0.6 | 0.9 | 49.7 |
| Krt71 | Keratin 71, type II | 0.2 | 0.1 | 0.9 | 10.4 | 4.2 | 0.7 | 1.5 | 49.5 |
| Tmprss4 | Transmembrane protease, serine 4 | 0.3 | 0.2 | 0.6 | 13.6 | 7.2 | 2.2 | 2.5 | 48.6 |
| Angptl4 | Angiopoietin‐like 4 | 0.6 | 1.1 | 14.6 | 27.2 | 21.8 | 3.1 | 6.5 | 47.7 |
| Ccl3 | C‐C motif chemokine ligand 3 | 2.1 | 41.0 | 99.8 | 56.1 | 30.4 | 8.0 | 11.8 | 46.6 |
| Serpinb3 | Serpin family B member 3 | 0.9 | 0.9 | 14.3 | 35.8 | 39.3 | 28.8 | 42.2 | 44.9 |
| Rbp1 | Retinol‐binding protein 1 | 2.5 | 2.5 | 7.8 | 108.0 | 74.6 | 18.5 | 33.8 | 43.7 |
| Mt2A | Metallothionein 2A | 49.5 | 324.9 | 2068.9 | 652.2 | 312.8 | 106.5 | 117.4 | 41.8 |
| Uox | Urate oxidase | 2.1 | 0.8 | 58.2 | 84.5 | 56.0 | 10.9 | 21.8 | 41.0 |
| Ccl7 | C‐C motif chemokine ligand 7 | 10.0 | 99.1 | 402.9 | 213.6 | 97.1 | 52.7 | 49.1 | 40.2 |
| Hist1h2bk | Histone cluster 1, h2bk | 0.3 | 0.3 | 0.6 | 10.2 | 10.4 | 1.7 | 1.8 | 40.0 |
Although the actual sFPKM values of measurement had two decimal places, the values were rounded off and expressed using one decimal place in this table. The expression ratio was calculated using the actual values. The actual values are found in Table S1.
Abbreviations: d, day(s); hr, hours; Unt, untreated control.