TABLE 4.
Top 30 differentially induced genes in the incision secretome
| Gene symbol | Gene name | sFPKM | Expression ratio compared to Unt | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Unt | 1 hr | 6 hr | 1 d | 3 d | 6 d | 12 d | |||
| Nppb | Natriuretic peptide B | 0.2 | 0.1 | 44.4 | 152.6 | 15.0 | 0.8 | 7.6 | 1017.1 |
| Tnn | Tenascin N | 0.3 | 0.4 | 1.1 | 7.9 | 238.1 | 114.9 | 98.6 | 882.0 |
| Il6 | Interleukin 6 | 0.1 | 55.0 | 93.8 | 13.3 | 7.4 | 3.0 | 1.7 | 781.8 |
| Cxcl2 | C‐X‐C motif chemokine ligand 2 | 0.2 | 105.3 | 63.9 | 60.4 | 11.6 | 2.9 | 9.7 | 657.9 |
| Cxcl1 | C‐X‐C motif chemokine ligand 1 | 0.9 | 468.4 | 80.0 | 33.7 | 7.0 | 2.6 | 5.0 | 514.8 |
| Cxcl3 | C‐X‐C motif chemokine ligand 3 | 0.1 | 1.1 | 41.5 | 28.7 | 7.3 | 1.6 | 5.8 | 345.8 |
| Ptx3 | Pentraxin 3 | 1.1 | 12.2 | 184.4 | 83.3 | 25.6 | 7.7 | 7.9 | 170.7 |
| Reg3g | Regenerating family member 3 gamma | 0.1 | 0.1 | 22.8 | 3.5 | 0.9 | 0.2 | 0.2 | 163.0 |
| S100a8 | S100 calcium‐binding protein A8 | 23.9 | 129.9 | 1126.9 | 3585.5 | 996.8 | 117.8 | 576.5 | 150.2 |
| Gip | Gastric inhibitory polypeptide | 0.1 | 0.1 | 0.9 | 17.5 | 9.0 | 0.8 | 1.2 | 145.4 |
| Ifnk | Interferon kappa | 0.1 | 0.1 | 7.3 | 15.7 | 3.0 | 2.1 | 0.8 | 121.0 |
| Defb4 | Defensin beta 4 | 1.3 | 2.4 | 101.5 | 138.2 | 77.5 | 25.0 | 52.0 | 110.5 |
| Il24 | Interleukin 24 | 1.8 | 3.0 | 55.7 | 167.8 | 10.2 | 2.6 | 7.7 | 91.7 |
| Mmp12 | Matrix metallopeptidase 12 | 0.3 | 0.2 | 7.8 | 24.2 | 22.7 | 16.4 | 23.4 | 75.5 |
| Il1b | Interleukin 1 beta | 2.0 | 68.1 | 141.7 | 62.3 | 25.5 | 10.6 | 24.3 | 69.8 |
| Ccl12 | C‐C motif chemokine ligand 12 | 0.2 | 0.2 | 11.7 | 5.7 | 9.0 | 4.9 | 3.0 | 58.7 |
| Osm | Oncostatin M | 0.4 | 9.4 | 23.4 | 4.4 | 3.2 | 1.1 | 2.0 | 54.4 |
| Cxcl6 | C‐X‐C motif chemokine ligand 6 | 0.1 | 0.1 | 5.8 | 3.1 | 1.3 | 0.4 | 0.7 | 53.0 |
| Fcnb | Ficolin B | 4.6 | 8.8 | 231.0 | 29.7 | 21.2 | 5.2 | 4.8 | 50.0 |
| Ccl3 | C‐C motif chemokine ligand 3 | 2.1 | 41.0 | 99.8 | 56.1 | 30.4 | 8.0 | 11.8 | 46.6 |
| Ccl7 | C‐C motif chemokine ligand 7 | 10.0 | 99.1 | 402.9 | 213.6 | 97.1 | 52.7 | 49.1 | 40.2 |
| Il10 | Interleukin 10 | 0.2 | 6.0 | 0.7 | 0.8 | 0.6 | 0.3 | 0.5 | 37.6 |
| Lcn2 | Lipocalin 2 | 2.6 | 3.4 | 58.9 | 61.3 | 94.8 | 45.3 | 28.7 | 36.3 |
| Defb14 | Defensin beta 14 | 1.4 | 0.8 | 28.3 | 49.3 | 19.0 | 3.1 | 19.3 | 36.0 |
| Serpine1 | Serpin family E member 1 | 8.4 | 151.2 | 282.7 | 151.0 | 172.7 | 47.4 | 110.4 | 33.7 |
| Apoc4 | Apolipoprotein C4 | 0.2 | 0.2 | 0.2 | 0.5 | 5.3 | 4.9 | 4.0 | 33.3 |
| Ccl17 | C‐C motif chemokine ligand 17 | 0.3 | 1.1 | 7.5 | 1.3 | 1.0 | 0.6 | 1.3 | 28.9 |
| Mmp9 | Matrix metallopeptidase 9 | 0.6 | 1.1 | 8.6 | 17.3 | 8.5 | 2.4 | 8.7 | 28.8 |
| Mmp13 | Matrix metallopeptidase 13 | 1.5 | 0.2 | 10.1 | 42.2 | 12.6 | 3.4 | 11.1 | 28.5 |
| Ccl20 | C‐C motif chemokine ligand 20 | 0.5 | 1.9 | 14.9 | 11.4 | 1.9 | 0.3 | 1.0 | 28.1 |
Although the actual sFPKM values of measurement had two decimal places, the values were rounded off and expressed using one decimal place in this table. The expression ratio was calculated using the actual values. The actual values are found in Table S1.
Abbreviations: d, days; hr, hours; Max, maximum expression level; Unt, untreated control.