TABLE 7.
Top 50 differentially expressed common genes between the incision and inflammation models
| Gene symbol | Gene name | Incision | Inflammation | ||||
|---|---|---|---|---|---|---|---|
| Unt | Max | Expression ratio compared to Unt | Unt | Max | Expression ratio compared to Unt | ||
| Nppb | Natriuretic peptide B | 0.2 | 152.6 | 1017.1 | 0.2 | 2.4 | 15.1 |
| Tnn | Tenascin N | 0.3 | 238.1 | 882.0 | 1.2 | 4.2 | 3.6 |
| Krt17 | Keratin 17 | 10.1 | 8747.5 | 868.7 | 36.2 | 156.5 | 4.3 |
| Il6 | Interleukin 6 | 0.1 | 93.8 | 781.8 | 0.2 | 29.9 | 199.3 |
| Cxcl2 | C‐X‐C motif chemokine ligand 2 | 0.2 | 105.3 | 657.9 | 0.2 | 27.6 | 172.3 |
| Cxcl1 | C‐X‐C motif chemokine ligand 1 | 0.9 | 468.4 | 514.8 | 0.6 | 36.7 | 66.8 |
| Stfa2l1 | Stefin A2‐like 1 | 0.2 | 73.5 | 408.3 | 0.2 | 3.6 | 15.5 |
| Cxcl3 | C‐X‐C motif chemokine ligand 3 | 0.1 | 41.5 | 345.8 | 0.1 | 2.5 | 19.2 |
| S100a9 | S100 calcium‐binding protein A9 | 20.9 | 5075.9 | 242.4 | 1.5 | 249.0 | 169.4 |
| Slpi | Secretory leukocyte peptidase inhibitor | 4.0 | 817.6 | 202.4 | 4.9 | 44.6 | 9.1 |
| Sh2d5 | SH2 domain containing 5 | 0.1 | 19.3 | 175.5 | 0.1 | 2.4 | 22.0 |
| Ptx3 | Pentraxin 3 | 1.1 | 184.4 | 170.7 | 1.6 | 283.8 | 174.1 |
| Reg3g | Regenerating family member 3 gamma | 0.1 | 22.8 | 163.0 | 0.2 | 2.2 | 13.8 |
| S100a8 | S100 calcium‐binding protein A8 | 23.9 | 3585.5 | 150.2 | 36.4 | 310.7 | 8.5 |
| Stfa2l2 | Stefin A2‐like 2 | 10.7 | 1568.6 | 146.3 | 10.5 | 45.7 | 4.3 |
| Stfa2 | Stefin A2 | 42.2 | 5359.0 | 127.1 | 30.8 | 164.2 | 5.3 |
| Ifnk | Interferon kappa | 0.1 | 15.7 | 121.0 | 0.1 | 0.4 | 2.6 |
| Defb4 | Defensin beta 4 | 1.3 | 138.2 | 110.5 | 1.5 | 8.1 | 5.3 |
| Nat8l | N‐acetyltransferase 8‐like | 0.4 | 40.3 | 108.8 | 6.2 | 17.0 | 2.8 |
| Ear1 | Eosinophil‐associated, ribonuclease A family, member 1 | 0.1 | 12.2 | 87.1 | 0.2 | 0.5 | 2.4 |
| Areg | Amphiregulin | 1.1 | 94.5 | 85.9 | 0.1 | 0.6 | 4.8 |
| Mmp12 | Matrix metallopeptidase 12 | 0.3 | 24.2 | 75.5 | 0.5 | 2.6 | 5.3 |
| Slc6a14 | Solute carrier family 6 member 14 | 0.1 | 10.5 | 75.1 | 0.7 | 2.4 | 3.7 |
| Il1b | Interleukin 1 beta | 2.0 | 141.7 | 69.8 | 1.3 | 36.5 | 28.9 |
| Tarm1 | T cell‐interacting, activating receptor on myeloid cells 1 | 0.1 | 7.7 | 64.4 | 0.1 | 1.3 | 11.7 |
| Fcar | Fc fragment of iga receptor | 0.1 | 8.2 | 62.8 | 0.1 | 1.0 | 8.2 |
| Hmox1 | Heme oxygenase 1 | 17.9 | 1125.7 | 62.7 | 19.3 | 338.4 | 17.5 |
| Mcemp1 | Mast cell‐expressed membrane protein 1 | 0.8 | 45.0 | 60.0 | 0.2 | 4.0 | 23.3 |
| Ccl12 | C‐C motif chemokine ligand 12 | 0.2 | 11.7 | 58.7 | 0.2 | 33.0 | 183.1 |
| Fosb | Fosb proto‐oncogene, AP‐1 transcription factor subunit | 4.3 | 245.8 | 56.8 | 5.1 | 67.8 | 13.2 |
| Sirpb2l1 | Signal‐regulatory protein beta 2‐like 1 | 0.4 | 19.8 | 53.5 | 0.1 | 2.8 | 19.8 |
| Cxcl6 | C‐X‐C motif chemokine ligand 6 | 0.1 | 5.8 | 53.0 | 0.1 | 1.6 | 14.2 |
| Fcnb | Ficolin B | 4.6 | 231.0 | 50.0 | 0.4 | 51.9 | 140.4 |
| Oscar | Osteoclast associated, immunoglobulin‐like receptor | 0.3 | 16.4 | 49.7 | 0.1 | 2.8 | 25.1 |
| Ccl3 | C‐C motif chemokine ligand 3 | 2.1 | 99.8 | 46.6 | 0.3 | 15.9 | 61.2 |
| Ccl7 | C‐C motif chemokine ligand 7 | 10.0 | 402.9 | 40.2 | 5.5 | 150.7 | 27.4 |
| Csf3r | Colony stimulating factor 3 receptor | 1.9 | 75.8 | 39.3 | 0.2 | 10.8 | 51.4 |
| Irg1 | Immunoresponsive gene 1 | 0.1 | 4.0 | 36.7 | 0.1 | 4.3 | 39.5 |
| Serpine1 | Serpin family E member 1 | 8.4 | 282.7 | 33.7 | 4.1 | 176.4 | 43.3 |
| Clec4a2 | C‐type lectin domain family 4, member A2 | 0.6 | 14.3 | 24.6 | 0.2 | 18.4 | 79.9 |
| Cd300ld | Cd300 molecule‐like family member D | 1.2 | 23.6 | 19.2 | 0.2 | 9.7 | 54.0 |
| Lilrb3 | Leukocyte immunoglobulin like receptor B3 | 0.3 | 5.6 | 17.6 | 0.8 | 71.3 | 85.9 |
| Hk3 | Hexokinase 3 | 0.3 | 5.6 | 17.6 | 0.2 | 19.1 | 82.8 |
| Sell | Selectin L | 2.5 | 39.3 | 15.8 | 0.2 | 18.5 | 84.3 |
| Fcgr3a | Fc fragment of igg, low affinity iiia, receptor | 0.6 | 7.6 | 12.7 | 0.2 | 14.0 | 63.6 |
| Ebi3 | Epstein‐Barr virus induced 3 | 1.0 | 11.7 | 12.2 | 0.2 | 13.0 | 56.7 |
| Spp1 | Secreted phosphoprotein 1 | 49.4 | 434.8 | 8.8 | 5.2 | 956.4 | 182.5 |
| Mx1 | Myxovirus (influenza virus) resistance 1 | 1.3 | 10.0 | 8.0 | 1.5 | 121.0 | 79.1 |
| Ankrd1 | Ankyrin repeat domain 1 | 22.7 | 179.2 | 7.9 | 0.6 | 54.7 | 91.1 |
| Ankrd2 | Ankyrin repeat domain 2 | 21.2 | 81.4 | 3.9 | 0.2 | 21.3 | 118.1 |
Although the actual sFPKM values of measurement had two decimal places, the values were rounded off and expressed using one decimal place in this table. The expression ratio was calculated using the actual values. The actual values are found in Table S1.
Abbreviations: Max, maximum expression level; Unt, untreated control.