TABLE 8.
Top 50 differentially induced genes in incision‐specific genes
| Gene symbol | Gene name | sFPKM | Expression ratio compared to Unt | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Unt | 1 hr | 6 hr | 1d | 3 d | 6 d | 12 d | |||
| Klk6 | Kallikrein‐related peptidase 6 | 0.3 | 0.1 | 2.9 | 34.2 | 47.2 | 2.7 | 23.4 | 188.8 |
| Gip | Gastric inhibitory polypeptide | 0.1 | 0.1 | 0.9 | 17.5 | 9.0 | 0.8 | 1.2 | 145.4 |
| Stfa3 | Stefin A3 | 36.3 | 24.4 | 340.5 | 4522.3 | 3008.5 | 1512.6 | 738.5 | 124.5 |
| Il24 | Interleukin 24 | 1.8 | 3.0 | 55.7 | 167.8 | 10.2 | 2.6 | 7.7 | 91.7 |
| Krt71 | Keratin 71, type II | 0.2 | 0.1 | 0.9 | 10.4 | 4.2 | 0.7 | 1.5 | 49.5 |
| Tmprss4 | Transmembrane protease, serine 4 | 0.3 | 0.2 | 0.6 | 13.6 | 7.2 | 2.2 | 2.5 | 48.6 |
| Hist1h2bk | Histone cluster 1, h2bk | 0.3 | 0.3 | 0.6 | 10.2 | 10.4 | 1.7 | 1.8 | 40.0 |
| Dsc2 | Desmocollin 2 | 0.6 | 0.4 | 2.6 | 20.3 | 6.6 | 1.7 | 4.4 | 36.9 |
| Defb14 | Defensin beta 14 | 1.4 | 0.8 | 28.3 | 49.3 | 19.0 | 3.1 | 19.3 | 36.0 |
| Tmprss11b | Transmembrane protease, serine 11B | 0.1 | 0.1 | 0.1 | 0.8 | 3.8 | 0.2 | 2.8 | 34.5 |
| Rspo2 | R‐spondin 2 | 0.2 | 0.2 | 0.3 | 1.6 | 6.7 | 2.5 | 3.1 | 33.7 |
| S100a7a | S100 calcium‐binding protein A7A | 0.2 | 0.1 | 3.1 | 5.9 | 3.3 | 1.5 | 4.9 | 31.3 |
| Ptprz1 | Protein tyrosine phosphatase, receptor type Z1 | 1.6 | 1.1 | 5.1 | 40.0 | 8.5 | 4.1 | 5.4 | 25.7 |
| Elf3 | E74‐like factor 3 | 0.1 | 0.1 | 1.0 | 2.7 | 1.4 | 0.5 | 1.6 | 24.5 |
| Il19 | Interleukin 19 | 0.1 | 0.1 | 1.6 | 2.8 | 0.4 | 0.1 | 0.3 | 23.7 |
| Prss35 | Protease, serine, 35 | 0.3 | 0.3 | 0.1 | 0.2 | 4.0 | 7.1 | 5.5 | 22.9 |
| Tubb2b | Tubulin, beta 2B class iib | 2.0 | 2.7 | 2.5 | 43.6 | 17.8 | 13.5 | 23.6 | 22.1 |
| Igf2bp1 | Insulin‐like growth factor 2 mrna‐binding protein 1 | 0.1 | 0.1 | 0.2 | 2.2 | 1.3 | 0.2 | 0.5 | 21.8 |
| Avp | Arginine vasopressin | 0.2 | 0.2 | 0.2 | 0.3 | 3.9 | 0.9 | 0.4 | 20.7 |
| Ear11 | Eosinophil‐associated, ribonuclease A family, member 11 | 0.1 | 0.1 | 0.2 | 2.8 | 2.2 | 0.8 | 2.4 | 20.2 |
| Ugt1a2 | UDP glucuronosyltransferase 1 family, polypeptide A2 | 0.1 | 0.1 | 0.9 | 2.4 | 0.3 | 0.2 | 0.3 | 20.2 |
| Camp | Cathelicidin antimicrobial peptide | 0.2 | 2.5 | 4.4 | 1.9 | 0.3 | 0.3 | 0.4 | 20.1 |
| Krt5 | Keratin 5 | 246.8 | 187.3 | 622.2 | 4889.6 | 1840.6 | 586.9 | 742.7 | 19.8 |
| Exo1 | Exonuclease 1 | 0.2 | 0.1 | 0.3 | 3.4 | 2.6 | 0.5 | 0.6 | 19.7 |
| Lamc2 | Laminin subunit gamma 2 | 7.5 | 7.0 | 56.5 | 145.8 | 45.2 | 11.1 | 36.3 | 19.5 |
| Gbx2 | Gastrulation brain homeobox 2 | 0.1 | 0.1 | 0.2 | 1.0 | 2.1 | 0.3 | 1.3 | 19.4 |
| Sstr4 | Somatostatin receptor 4 | 0.1 | 0.2 | 2.3 | 0.5 | 0.3 | 0.4 | 0.2 | 19.3 |
| Tmem8c | Transmembrane protein 8C | 0.2 | 0.2 | 0.1 | 0.1 | 0.8 | 1.7 | 3.4 | 18.8 |
| Podnl1 | Podocan‐like 1 | 0.2 | 0.1 | 0.1 | 0.2 | 1.0 | 2.6 | 3.0 | 18.6 |
| Aard | Alanine and arginine rich domain containing protein | 0.1 | 0.2 | 0.1 | 0.2 | 0.5 | 2.2 | 2.4 | 18.5 |
| Il20 | Interleukin 20 | 0.1 | 0.1 | 1.0 | 2.2 | 0.2 | 0.1 | 0.2 | 18.3 |
| Gjb2 | Gap junction protein, beta 2 | 41.2 | 21.1 | 113.2 | 744.7 | 305.8 | 98.1 | 118.3 | 18.1 |
| Tgfa | Transforming growth factor alpha | 2.9 | 1.6 | 23.3 | 51.9 | 8.2 | 4.8 | 7.2 | 17.8 |
| Hist1h3a | Histone cluster 1, h3a | 0.2 | 0.2 | 0.2 | 2.8 | 2.4 | 0.7 | 0.3 | 17.7 |
| Ptprv | Protein tyrosine phosphatase, receptor type, V | 1.2 | 0.9 | 0.8 | 2.4 | 16.6 | 21.2 | 17.2 | 17.5 |
| Chrng | Cholinergic receptor nicotinic gamma subunit | 0.4 | 0.5 | 0.2 | 0.3 | 1.7 | 3.2 | 6.3 | 16.6 |
| Spon1 | Spondin 1 | 8.5 | 8.0 | 14.6 | 38.3 | 110.7 | 135.2 | 103.1 | 15.9 |
| Tuba1c | Tubulin, alpha 1C | 0.7 | 0.9 | 3.9 | 10.7 | 4.1 | 2.3 | 4.0 | 15.9 |
| Lama3 | Laminin subunit alpha 3 | 9.1 | 7.3 | 37.9 | 143.9 | 42.6 | 21.3 | 35.4 | 15.7 |
| Cenpu | Centromere protein U | 0.5 | 0.5 | 1.0 | 8.3 | 6.3 | 1.1 | 1.6 | 15.6 |
| Rrm2 | Ribonucleotide reductase regulatory subunit M2 | 0.9 | 0.8 | 1.6 | 14.0 | 10.8 | 2.1 | 3.0 | 15.5 |
| Has3 | Hyaluronan synthase 3 | 1.2 | 1.2 | 3.5 | 18.7 | 3.6 | 2.0 | 3.8 | 15.5 |
| Adcy8 | Adenylate cyclase 8 | 0.1 | 0.1 | 0.1 | 1.2 | 1.5 | 0.2 | 0.3 | 15.4 |
| Mybl2 | Myeloblastosis oncogene‐like 2 | 0.7 | 0.6 | 0.7 | 10.5 | 10.3 | 1.8 | 2.7 | 15.2 |
| Cdkn1c | Cyclin‐dependent kinase inhibitor 1C | 6.9 | 6.6 | 3.8 | 4.2 | 13.8 | 103.8 | 52.6 | 15.1 |
| Csf2 | Colony stimulating factor 2 | 0.2 | 0.4 | 2.9 | 0.3 | 0.4 | 0.3 | 0.6 | 15.1 |
| Ccne1 | Cyclin E1 | 0.6 | 0.5 | 0.8 | 8.7 | 5.7 | 2.1 | 1.9 | 14.7 |
| Nrg1 | Neuregulin 1 | 1.7 | 1.2 | 12.2 | 24.8 | 5.1 | 1.7 | 4.2 | 14.7 |
| S100vp | S100 calcium‐binding protein, ventral prostate | 3.4 | 1.2 | 0.7 | 0.4 | 0.2 | 48.8 | 11.4 | 14.3 |
| Hhipl1 | HHIP‐like 1 | 1.2 | 1.4 | 0.6 | 2.6 | 16.4 | 14.1 | 15.0 | 14.2 |
Although the actual sFPKM values of measurement had two decimal places, the values were rounded off and expressed using one decimal place in this table. The expression ratio was calculated using the actual values. The actual values are found in Table S1.
Abbreviations: d, day(s); hr, hours; Unt, untreated control.