TABLE 9.
Top 50 differentially induced genes in incision‐specific secretome
| Gene symbol | Gene name | sFPKM | Expression ratio compared to Unt | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Unt | 1 hr | 6 hr | 1 d | 3 d | 6 d | 12 d | |||
| Gip | gastric inhibitory polypeptide | 0.1 | 0.1 | 0.9 | 17.5 | 9.0 | 0.8 | 1.2 | 145.4 |
| Il24 | interleukin 24 | 1.8 | 3.0 | 55.7 | 167.8 | 10.2 | 2.6 | 7.7 | 91.7 |
| Defb14 | defensin beta 14 | 1.4 | 0.8 | 28.3 | 49.3 | 19.0 | 3.1 | 19.3 | 36.0 |
| Il19 | interleukin 19 | 0.1 | 0.1 | 1.6 | 2.8 | 0.4 | 0.1 | 0.3 | 23.7 |
| Avp | arginine vasopressin | 0.2 | 0.2 | 0.2 | 0.3 | 3.9 | 0.9 | 0.4 | 20.7 |
| Camp | cathelicidin antimicrobial peptide | 0.2 | 2.5 | 4.4 | 1.9 | 0.3 | 0.3 | 0.4 | 20.1 |
| Il20 | interleukin 20 | 0.1 | 0.1 | 1.0 | 2.2 | 0.2 | 0.1 | 0.2 | 18.3 |
| Tgfa | transforming growth factor alpha | 2.9 | 1.6 | 23.3 | 51.9 | 8.2 | 4.8 | 7.2 | 17.8 |
| Csf2 | colony stimulating factor 2 | 0.2 | 0.4 | 2.9 | 0.3 | 0.4 | 0.3 | 0.6 | 15.1 |
| Lamb3 | laminin subunit beta 3 | 4.0 | 3.2 | 26.2 | 55.3 | 19.1 | 8.8 | 17.7 | 13.9 |
| Lrg1 | leucine‐rich alpha‐2‐glycoprotein 1 | 12.4 | 52.9 | 169.5 | 31.0 | 28.1 | 22.9 | 21.4 | 13.7 |
| Emilin1 | elastin microfibril interfacer 1 | 3.9 | 4.2 | 3.3 | 17.2 | 52.1 | 29.8 | 24.2 | 13.5 |
| Adm2 | adrenomedullin 2 | 0.4 | 0.2 | 1.4 | 4.4 | 1.8 | 0.6 | 0.6 | 11.6 |
| Il17b | interleukin 17B | 2.2 | 1.7 | 3.2 | 24.5 | 11.6 | 7.4 | 7.3 | 11.0 |
| Scg2 | secretogranin II | 0.1 | 0.1 | 0.1 | 0.1 | 0.2 | 0.6 | 1.2 | 10.7 |
| Sfrp2 | secreted frizzled‐related protein 2 | 12.0 | 10.5 | 13.4 | 22.4 | 126.4 | 107.3 | 68.1 | 10.6 |
| Spp2 | secreted phosphoprotein 2 | 0.1 | 0.1 | 0.1 | 0.1 | 1.2 | 1.4 | 1.4 | 10.2 |
| Tac3 | tachykinin 3 | 0.2 | 0.4 | 0.4 | 0.3 | 0.9 | 2.2 | 2.4 | 10.2 |
| Il22ra2 | interleukin 22 receptor subunit alpha 2 | 0.1 | 0.3 | 1.2 | 0.3 | 0.2 | 0.2 | 0.2 | 9.6 |
| Igfbp4 | insulin‐like growth factor‐binding protein 4 | 55.8 | 73.1 | 122.0 | 295.4 | 521.0 | 467.0 | 425.5 | 9.3 |
| Aebp1 | AE‐binding protein 1 | 39.9 | 44.1 | 55.7 | 64.5 | 201.4 | 324.1 | 263.5 | 8.1 |
| Serpinb1a | serine (or cysteine) proteinase inhibitor, clade B, member 1a | 37.2 | 42.8 | 95.7 | 301.5 | 160.7 | 66.4 | 71.2 | 8.1 |
| Lum | lumican | 193.9 | 226.7 | 147.5 | 282.5 | 1492.4 | 1418.4 | 979.0 | 7.7 |
| Wnt10a | wingless‐type MMTV integration site family, member 10A | 0.8 | 0.7 | 2.2 | 5.8 | 2.0 | 1.2 | 1.4 | 7.3 |
| Erfe | erythroferrone | 0.4 | 0.8 | 0.5 | 2.2 | 2.6 | 1.1 | 1.3 | 6.8 |
| Penk | proenkephalin | 1.5 | 2.9 | 2.4 | 1.5 | 10.1 | 5.4 | 8.0 | 6.7 |
| Serpinb2 | serpin family B member 2 | 55.8 | 40.5 | 241.4 | 363.3 | 62.1 | 45.0 | 62.4 | 6.5 |
| Wnt4 | wingless‐type MMTV integration site family, member 4 | 4.6 | 3.5 | 10.3 | 29.0 | 8.0 | 5.7 | 6.2 | 6.3 |
| Col27a1 | collagen, type XXVII, alpha 1 | 5.0 | 4.4 | 6.6 | 5.1 | 27.9 | 12.0 | 11.4 | 5.6 |
| Vstm1 | V‐set and transmembrane domain containing 1 | 0.7 | 2.1 | 3.6 | 0.7 | 0.5 | 0.6 | 0.4 | 5.1 |
| Arsi | arylsulfatase family, member I | 4.4 | 4.8 | 5.9 | 15.9 | 15.7 | 10.7 | 21.7 | 5.0 |
| Il23a | interleukin 23 subunit alpha | 0.5 | 0.6 | 1.6 | 2.5 | 0.8 | 0.8 | 1.0 | 4.9 |
| Mmp2 | matrix metallopeptidase 2 | 191.2 | 242.8 | 186.3 | 143.3 | 379.9 | 912.3 | 794.5 | 4.8 |
| Gal | galanin and GMAP prepropeptide | 0.3 | 0.2 | 0.3 | 0.2 | 0.6 | 0.4 | 1.4 | 4.8 |
| Srpx2 | sushi‐repeat‐containing protein, X‐linked 2 | 13.3 | 12.9 | 8.2 | 14.7 | 53.3 | 62.3 | 55.5 | 4.7 |
| Adamtsl1 | ADAMTS‐like 1 | 2.1 | 3.0 | 5.1 | 3.0 | 5.9 | 9.4 | 5.9 | 4.4 |
| Ptn | pleiotrophin | 22.9 | 20.0 | 16.7 | 21.6 | 84.9 | 99.2 | 69.8 | 4.3 |
| Vwa1 | von Willebrand factor A domain containing 1 | 9.6 | 9.5 | 12.7 | 40.5 | 33.4 | 18.9 | 22.9 | 4.2 |
| Mmp23 | matrix metallopeptidase 23 | 8.7 | 9.9 | 6.7 | 5.2 | 22.2 | 35.5 | 28.7 | 4.1 |
| Igfbp3 | insulin‐like growth factor‐binding protein 3 | 10.5 | 10.4 | 16.6 | 42.6 | 32.4 | 24.2 | 34.3 | 4.1 |
| Adamts7 | ADAM metallopeptidase with thrombospondin type 1 motif, 7 | 2.5 | 2.3 | 3.3 | 3.0 | 6.5 | 10.2 | 9.1 | 4.0 |
| Plod3 | procollagen‐lysine, 2‐oxoglutarate 5‐dioxygenase 3 | 11.6 | 13.1 | 23.6 | 23.5 | 45.3 | 25.0 | 25.5 | 3.9 |
| Ndnf | neuron‐derived neurotrophic factor | 0.4 | 0.5 | 0.2 | 0.4 | 1.1 | 1.5 | 0.8 | 3.8 |
| Anxa2 | annexin A2 | 676.3 | 650.2 | 1353.9 | 2549.0 | 1571.8 | 914.5 | 1390.4 | 3.8 |
| Cxcl12 | C‐X‐C motif chemokine ligand 12 | 24.6 | 22.0 | 23.0 | 23.9 | 42.3 | 91.2 | 76.7 | 3.7 |
| Pgf | placental growth factor | 4.0 | 4.8 | 5.9 | 9.3 | 14.1 | 6.3 | 10.3 | 3.5 |
| Hamp | hepcidin antimicrobial peptide | 0.6 | 0.3 | 2.0 | 0.3 | 0.2 | 0.3 | 0.2 | 3.4 |
| Igf2 | insulin‐like growth factor 2 | 19.2 | 16.7 | 12.5 | 5.4 | 9.2 | 41.4 | 64.8 | 3.4 |
| Il34 | interleukin 34 | 3.4 | 3.3 | 2.6 | 2.5 | 3.8 | 11.5 | 7.8 | 3.4 |
| Wisp2 | WNT1 inducible signaling pathway protein 2 | 58.4 | 72.2 | 19.0 | 72.1 | 106.9 | 189.9 | 121.9 | 3.3 |
Although the actual sFPKM values of measurement had two decimal places, the values were rounded off and expressed using one decimal place in this table. The expression ratio was calculated using the actual values. The actual values are found in Table S1.
Abbreviations: d, day(s); hr, hours; Unt, untreated control.