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. 2021 Oct 1;16(23):3513–3544. doi: 10.1002/cmdc.202100503

Scheme 42.

Scheme 42

Synthesis of peptidyl aziridines plasmodial proteases inhibitors :  (A) synthesis of diastereomeric N‐alkylated aziridine‐2‐carboxylic acid‐based inhibitor 249; (B) synthesis of N‐acylated aziridine‐2,3‐dicarboxylic acid‐based inhibitors 250 and 251.