Table 2.

Multivariable logistic regression models for the prediction of lymph node metastasis, ≥pT3 disease, and any nonorgan confined disease in 1029 patients treated with radical cystectomy for urothelial carcinoma of the bladder

Variable	Lymph node involvement			≥pT3 disease			Any nonorgan confined disease
	OR	95% CI	p value	OR	95% CI	p value	OR	95% CI	p value
Endoglin	1.72	1.52, 1.97	<0.001	1.53	1.37, 1.72	<0.001	1.61	1.44, 1.81	<0.001
Age	1.00	0.98, 1.01	0.9	1.03	1.01, 1.04	<0.001	1.02	1.01, 1.04	0.001
Gender (female)	1.40	0.98, 1.99	0.06	1.02	0.73, 1.42	0.9	1.14	0.82, 1.59	0.4
Clinical tumor stage
cTa/cTis/cT1	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref
cT2	2.38	1.72, 3.30	<0.001	2.64	1.99, 3.51	<0.001	2.96	2.25, 3.91	<0.001
≥cT3	3.13	1.74, 5.55	<0.001	8.83	4.89, 16.7	<0.001	8.25	4.44, 16.2	<0.001
AUC with endoglin	0.733			0.725			0.734
AUC without endoglin	0.629			0.675			0.676
DeLong's test p value	<0.001			<0.001			<0.001

Note: Bold p values are statistically significant.

Abbreviations: AUC, area under the curve; CI, confidence interval; OR, odds ratio. CI, confidence interval.