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. 2021 Oct 4;48(12):1537–1548. doi: 10.1111/jcpe.13545

TABLE 1.

Prevalence of self‐reported GBoB, concentrations, and total amounts of Hb according to different periodontal statuses

GBoB estimates (a) Periodontal case definitions
Periodontal health (n = 66) Gingivitis (n = 62) Periodontitis (n = 280) p‐Value
Self‐reported GBoB 10 (15.6%)a 38 (61.3%)b 104 (37.1%)c <.001
Hb concentration (μg/ml) 56.71a (34.48–117.70) 104.91b (57.72–239.56) 90.18b (55.17–176.56) <.001
>Detection limit (90.08 μg/ml) 21 (31.8%)a 35 (56.5%)b 139 (49.8%)b .011
Total amount of Hb (μg) 35.99a (24.41–60.27) 119.37b (75.49–246.97) 93.06b (38.28–176.70) <.001
>Detection limit (70.05 μg) 9 (13.6%)a 44 (71.0%)b 154 (55.2%)b <.001
GBoB estimates (b) Stages of periodontitis
Stage I (n = 65) Stage II (n = 65) Stage III (n = 121) Stage IV (n = 29) p‐Value
Self‐reported GBoB 23 (35.4%) 25 (35.8%) 43 (35.5%) 12 (42.9%) .884
Hb concentration (μg/ml) 79.60 (54.12–200.97) 103.14 (59.91–201.48) 80.15 (56.56–165.83) 90.95 (47.99–273.88) .784
>Detection limit (90.08 μg/ml) 31 (47.7%) 37 (56.9%) 57 (47.1%) 14 (50.0%) .618
Total amount of Hb (μg) 120.74 (41.07–201.60) 82.69 (42.99–161.11) 84.48 (34.53–158.47) 100.91 (36.10–318.46) .328
>Detection limit (70.05 μg) 38 (58.8%) 35 (53.8%) 64 (52.9%) 17 (60.7%) .818
GBoB estimates (c) Gingival inflammatory status
BOP% < 10% (n = 90) 10% ≤ BOP% ≤ 30% (n = 220) BOP% > 30% (n = 98) p‐Value
Self‐reported GBoB 14 (15.6%)a 81 (36.8%)b 57 (58.2%)c <.001
Hb concentration (μg/ml) 56.71a (34.49–108.63) 76.59b (52.49–143.59) 168.90c (80.06–370.52) <.001
>Detection limit (90.08 μg/ml) 28 (31.1%)a 99 (45.2%)a 68 (69.4%)b <.001
Total amount of Hb (μg) 34.39a (23.56–52.90) 82.40b (38.43–133.86) 187.13c (93.29–376.32) <.001
>Detection limit (70.05 μg) 11 (12.2%)a 116 (50.3%)b 80 (81.6%)c <.00

Note: Data are presented as either median, interquartile range (IQR), or n (%). Chi‐square tests (for categorical data) and Kruskal–Wallis tests (for continuous data) were used to assess differences across groups. If group differences are indicated (p < .05), then pair‐wise comparisons between the groups were conducted using a Bonferroni method to adjust the significance level for the multiple comparisons. Values with different superscripts (e.g., a, b, and c) are significantly different. Stage I periodontitis; II, Stage II periodontitis; III, Stage III periodontitis; IV, Stage IV periodontitis.