TABLE 1.
Baseline patients' characteristics by baseline use of antigout medication
| Characteristic | Patients not on antigout medication (n = 6607) | Patients on antigout medication (n = 413) |
|---|---|---|
| Age, years | 63.0 (8.7) | 65.3 (7.8) |
| Female sex, n (%) | 1948 (29.5) | 56 (13.6) |
| Race, n (%) | ||
| White | 4757 (72.0) | 324 (78.5) |
| Black | 342 (5.2) | 15 (3.6) |
| Asian | 1448 (21.9) | 69 (16.7) |
| Others | 60 (0.9) | 5 (1.2) |
| BMI, kg/m2 | 30.5 (5.2) | 32.5 (5.3) |
| Time since T2D diagnosis, n (%) | ||
| ≤1 year | 166 (2.5) | 14 (3.4) |
| >1‐5 years | 1031 (15.6) | 52 (12.6) |
| >5‐10 years | 1649 (25.0) | 97 (23.5) |
| >10 years | 3761 (56.9) | 250 (60.5) |
| Uric acid, mg/dL | 5.9 (1.6) | 6.4 (1.7) |
| eGFR, mL/min/1.73 m2 | 74.9 (21.3) | 60.0 (18.4) |
| Heart failure, n (%) | 651 (9.9) | 55 (13.3) |
| Hypertension, n (%) | 6024 (91.2) | 395 (95.6) |
| Median (IQR) UACR, mg/g creatinine | 16.8 (6.2‐69.8) | 30.9 (8.8‐127.3) |
| HbA1c, % | 8.1 (0.9) | 8.0 (0.8) |
| FPG, mg/dL | 153 (44) | 154 (42) |
| SBP, mmHg | 135 (17) | 136 (17) |
| DBP, mmHg | 77 (10) | 76 (10) |
| Cholesterol, mg/dL | 163 (44) | 155 (39) |
| Triglycerides, mg/dL | 169 (128) | 188 (114) |
| Loop diuretics, n (%) | 938 (14.2) | 150 (36.3) |
| Thiazide diuretics, n (%) | 1381 (20.9) | 106 (25.7) |
Note: Data are mean ± SD, unless otherwise stated.
Abbreviations: BMI, body mass index; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; FPG, fasting plasma glucose; HbA1c, glycated haemoglobin; SBP, systolic blood pressure; T2D, type 2 diabetes; UACR, urine albumin‐creatinine ratio.
Placebo and empagliflozin groups pooled for all variables.