. 2021 Sep 28;20(1):48–57. doi: 10.1111/jth.15530

TABLE 1.

Genome‐wide significant (P‐value <5 × 10⁻⁸) loci for thrombin generation traits

Trait	Top SNP	Gene	Chr	Position (bp)	Effect/alternative allele	MAF	Beta	P‐value
nETP‐TMsr	rs4241819	KLKB1 ^a , ^b , ^c	4	186235986	T/C	0.485	0.36	4.27 × 10⁻⁸
nPeak‐TMsr	rs4241819	KLKB1 ^a , ^b , ^c	4	186235986	T/C	0.484	0.37	1.97 × 10⁻⁸
ETP^TM+	rs404479	RP11‐315I14.2 ^a	9	23479588	T/G	0.433	0.46	4.03 × 10⁻⁸

Abbreviations: Chr, chromosome; ETP^TM+, endogenous thrombin potential in presence of thrombomodulin; MAF, minor allele frequency; nETP‐TMsr, normalized sensitivity ratio of endogenous thrombin potential to thrombomodulin; SNP, single‐nucleotide polymorphism.

^{^a}

Genes close to thrombin generation associated SNPs.

^{^b}

eQTL effect of thrombin generation associated SNPs based on publicly available databases. ³¹ , ³²

^{^c}

Missense in linkage disequilibrium variants (rs3733402).