TABLE 2.
Hypoglycaemic episodes reported in included studies
| Authors (year) | Reference | Measure characteristics | Occurrence of hypoglycaemia a | ||
|---|---|---|---|---|---|
| Type of record | Recall period (months) | Severity classification | |||
| Ali et al. (2012) | 35 | Yes/no | 12 | Grade 3 | 2.8% reported 1+ episodes |
| Briggs et al. (2017) | 20 | Yes/no | 12 | Grade 4 | 0.5% hospitalised for 1+ events |
| de Sonnaville et al. (1998) | 36 | Frequency | 1 | Grade 3 | 4.4 events per person‐year |
| Genovese et al. (2013) | 21 | Frequency | 12 | NR | NR |
| Goddijn et al. (1999) | 22 | Yes/no | 1 | Grade 2 | 6.4% and 19.1% reported 1+ episodes (at baseline and 1 year, respectively) |
| Haluzik et al. (2018) | 23 | Yes/no | 1 | Grades 1–2 | 57.0% and 53.7% reported 1+ episodes (at baseline and 1 month, respectively) |
| Grade 3 | 6.7% and 7.6% reported 1+ events (at baseline and 1 month, respectively) | ||||
| Jódar et al. (2020) | 24 | Yes/no | 26 | NR | 22.1% reported 1+ episodes |
| Malanda et al. (2011) | 25 | Yes/no | 12 | Grade 1 | 25.2% reported 1+ episodes |
| Grade 2 | 17.7% reported 1+ episodes | ||||
| Menard et al. (2007) | 26 | Yes//no | 12 | Grade 2 | 20.8% reported 1+ episodes |
| Frequency | Grade 2 | 21.6 episodes per person‐year | |||
| Mitchell et al. (2013) | 27 | Yes/no | 1 | Grades 1–3 | 27.5% reported 1+ episodes |
| Nauck et al. (2019) | 28 | Yes/no | 36 | Grade 3 | 42.3% reported 1+ events |
| Nicolucci et al. (2011) | 29 | Frequency | 1 | NR | 7.2, 19.2 and 21.6 episodes per person‐year (at 1, 5 and 6 months, respectively) |
| Pathan et al. (2018) | 38 | Yes/no | 1 | Grade 2–3 | 40.6% and 97.3.1% reported 1+ episodes (at baseline and 1 month, respectively) |
| Grade 3 | 52.2% and 76.9% reported 1+ events (at baseline b and 1 month, respectively) | ||||
| Frequency | Grade 2–3 | 12.2 and 22.6 episodes per person‐year (at baseline and 1 month, respectively) | |||
| Grade 3 | 2.2 and 12.2 events per person‐year (at baseline b and 1 month, respectively) | ||||
| Peyrot et al. (2008) | 30 | Frequency | 16 | Grade 2 | 2.3 episodes per person‐year |
| Pichayapinyo et al. (2019) | 31 | Severity | 3 | Grade 2 | NR |
| Polonsky et al. (2018) | 39 | Yes/no | 24 | Grade 2 | 86% reported 1+ episodes |
| Grade 3 | 41% reported 1+ events | ||||
| Ritter et al. (2016) | 37 | Symptom severity | 6 | NR | NR |
| Torre et al. (2019) | 32 | Yes/no | 26 | Grade 2–3 | 22.8% reported 1+ episodes |
| Grade 3 | <1% reported 1+ events | ||||
| Wieringa et al. (2018) | 33 | Yes/no | 3 | Grade 2–3 | 37.2%, 42.5% and 43.5% reported 1+ episodes (at baseline, 3 and 6 months, respectively) |
| Grade 3 | 3.1%, 4.3% and 5.6% reported 1+ events (at baseline, 3 and 6 months, respectively) | ||||
| Yang et al. (2014) | 34 | Frequency | 6 | Grade 2 | 2.17 and 1.54 episodes per person‐year (at baseline and 6 months, respectively) |
| Grade 3 | 0.15 and 0.0 events per person‐year (at baseline and 6 months, respectively) | ||||
Grade 1, asymptomatic hypoglycaemia; Grade 2, self‐treated symptomatic hypoglycaemia; Grade 3; severe hypoglycaemia requiring assistance; Grade 4, severe hypoglycaemia requiring hospitalisation.
Abbreviation: NR, not reported.
a
Unless otherwise stated, values reflect occurrence of hypoglycaemia during the study period. Occurrence of hypoglycaemia at baseline is presented when reported by the study.
b
Recall period was 6 months for baseline occurrence of severe (Grade 3) hypoglycaemic events.