Table 3.
Identification and change trends of biomarkers.
| HMDB | Measured mass | Formula | Mass error (ppm) | Compounds | Pathway | Change fold | |
|---|---|---|---|---|---|---|---|
| SG/MG | MG/BG | ||||||
| HMDB0002177 | 305.2482 | C20H32O2 | 2.14 | cis-8,11,14,17-Eicosatetraenoic acid | Linoleic acid metabolism | ↑∗∗ | ↓∗∗ |
| HMDB0006323 | 359.2949 | C24H38O2 | 1.36 | Tetracosapentaenoic acid (24:5n-3) | Linoleic acid metabolism | — | ↑∗∗ |
| HMDB0001381 | 375.2138 | C20H32O5 | -1.1 | Prostaglandin H2 | Arachidonic acid metabolism | ↑∗∗ | ↓∗∗∗ |
| HMDB0000277 | 379.2491 | C18H38NO5P | 0.99 | Sphingosine 1-phosphate | Sphingolipid metabolism | ↓∗∗ | ↑∗∗∗ |
| HMDB0000252 | 300.2891 | C18H37NO2 | -1.94 | Sphingosine | Sphingolipid metabolism | ↓ | — |
| HMDB0012225 | 164.0481 | C9H8O3 | 4.77 | Enol-phenylpyruvate | Phenylalanine metabolism | ↓∗∗ | ↑∗∗∗ |
| HMDB0002302 | 207.1131 | C11H11NO2 | 1.35 | Indole-3-propionic acid | Phenylalanine metabolism | ↓∗∗ | ↑∗∗ |
| HMDB0001903 | 417.3379 | C27H44O3 | 3.74 | Calcitriol | Vitamin B6 metabolism | — | ↓∗∗ |
| HMDB0004702 | 297.2436 | C18H32O3 | 4.1 | 12,13-EpOME | Oxylipin metabolism | — | ↓∗∗∗ |
| HMDB0001434 | 212.0927 | C10H13NO4 | 4.59 | 3-Methoxytyrosine | L-dopa degradation | ↓∗∗∗ | ↑∗∗∗ |
| HMDB0000913 | 230.1031 | C10H12O5 | 3.64 | Vanillactic acid | L-dopa degradation | ↓∗∗ | ↓∗∗ |
| HMDB0002057 | 1079.401 | C40H70N7O18P3S | -3.42 | Pristanoyl-CoA | Fatty acid metabolism | ↓∗∗ | ↑∗∗∗ |
| HMDB0002177 | 305.2482 | C20H32O2 | 2.14 | cis-8,11,14,17-Eicosatetraenoic acid | Linoleic acid metabolism | ↑∗∗ | ↓∗∗ |
Notes: n = 6, per group; data are expressed as mean ± SEM. The up (↑) and down (↓) arrows represent the relative increasing or decreasing trend of the metabolites;“—” represents no significant differences between SG and MG; a change trend of MG vs. NG, for a t-test, ∗∗∗P < 0.001 and ∗∗P < 0.05 (SG: Sc-At group; MG: model group; BG: blank group).