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. 2022 Jul 11;2022:2197071. doi: 10.1155/2022/2197071

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Copyright © 2022 Chao Wei et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Overexpression of KDM4A enhances cantharidin-induced DNA damage in liver cancer. (a) qRT-PCR of KDM4A in the control and KDM4A-overexpressing (KDM4A-oe) HepG2 and SMMC-7721 cells. (b) The expression of KDM4A and H3K36me3 in the normal and KDM4A-overexpressed hepatoma cells and in cantharidin-treated group. (c) The expression of H2AX was detected after different treatments, and the DNA damage of liver cancer cells was analyzed. KDM4A-HepG2 cells were treated with cantharidin (10 μM) for 48 h. (d) The expression of p21 was detected after different treatments, and the DNA damage of liver cancer cells was analyzed. KDM4A-HepG2 cells were treated with cantharidin (10 μM) for 48 h. (e) Detection of CCK-8 in HepG2 cells overexpressing KDM4A. Cells were treated with cantharidin (10 μM) for 48 h. ^∗p < 0.05, ^∗ ^∗p < 0.01.