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. 2022 Jul 13;31:101310. doi: 10.1016/j.bbrep.2022.101310

Fig. 1.

Fig. 1

miR combo induces cardiomyocyte gene expression in human cardiac fibroblasts.

Fetal human cardiac fibroblasts isolated from the left ventricle were transfected with miR combo or the non-targeting control miRNA negmiR. After 14 days, RNA was extracted and pooled from three separate transfections. Pooled RNA was analyzed by high-throughput sequencing. Sequences were matched to the human genome and genes significantly up- and down-regulated by miR combo were determined. Up- and down-regulated genes were analyzed via gene ontology to determine their function.

(A) Enrichment analysis displaying Gene Ontology (GO) terms which are over-represented in the set of genes up-regulated by miR combo.

(B) Enrichment analysis displaying Gene Ontology (GO) terms which are under-represented in the set of genes up-regulated by miR combo.

(C) Enrichment analysis displaying Gene Ontology (GO) terms which are over-represented in the set of genes down-regulated by miR combo.