Figure 1.

Pre-study liver biopsy and baseline RNA transcriptome data according to three different non-alcoholic fatty liver disease (NAFLD) models. A biopsy-proven NAFLD model was used to increase the response rate to the drug by performing a liver biopsy before drug administration through various liver disease models. (A) Diagram showing the treatment schedule for the pre-study biopsy. (B) Body weight and food intake change over time. (C) Representative images of hematoxylin and eosin (H&E) staining of pre-study biopsy liver tissue from mice fed various diets (original magnification, ×20). (D) NAFLD activity scores. (E) Multidimensional scaling and Database for Annotation, Visualization, and Integrated Discovery functional enrichment analyses performed for RNA-seq data from liver tissues of mice with various liver diseases. HFD, high-fat diet; MCD, methionine-choline deficient diet; WD, Western diet.