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. 2022 Apr 28;28(3):497–509. doi: 10.3350/cmh.2022.0019

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Copyright © 2022 by The Korean Association for the Study of the Liver

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Insulin-like growth factor-binding protein (IGFBP)-1 correlation between the serum and liver in the development study. (A) Comparison of serum IGFBP-1 (sIGFBP-1) levels in various dipeptidyl peptidase (DPP)-4 inhibitor studies. (B) Comparison of liver and sIGFBP-1 expression after administration according to IGFBP-1 expression level before administration in various DPP-4 inhibitor studies. (C) Result of correlation analysis between sIGFBP-1 and alanine aminotransferase (ALT), aspartate aminotransferase (AST), and triglyceride (TG) levels in various DPP-4 inhibitor studies. (D) Correlation analysis between liver and serum IGFBP-1 levels in various DPP-4 inhibitor studies. All data are expressed as the mean±standard deviation. NC, normal chow; CDHF, choline-deficient high-fat diet; HFD, high-fat diet. *P=0.01–0.05. **P=0.001–0.01.