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. 2022 May 4;28(3):522–539. doi: 10.3350/cmh.2022.0039

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Copyright © 2022 by The Korean Association for the Study of the Liver

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Alcohol consumption increases neutrophil extracellular traps (NETs) in both human and mice. (A-C) Serum MPO-DNA, lipopolysaccharide (LPS), and interleukin (IL)-6 levels from alcoholic liver disease (ALD), hepatocellular carcinoma (HCC), ALD+HCC, and control patients were detected by ELISA. (D, E) Correlation between serum LPS and MPO-DNA in patients with ALD and ALD+HCC. (F) Liver MPO-DNA levels in the mouse models of alcoholic hepatosteatosis and HCC were detected by ELISA. (G, H) Mouse livers were tested for NETs by detecting the expression of citrullinated histone H3 (Cit H3) and neutrophil elastase (NE) by immunofluorescence in both alcoholic hepatosteatosis and alcoholic HCC models (scale bar, 50 μm). OD, optical density; DAPI, 4’,6-diamidino-2-phenylindole; EtOH, ethanol; DEN, diethylnitrosamine; KO, knockout. *P<0.05 compared between groups (5–8 mice per experimental group).