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Design of bispecific IgE molecules.A, IgG bispecific antibody with Efab domain substitution in which CL and Cγ1 domains in one Fab were replaced with Cε2 domains featuring KiH mutations. B, IgE bispecific with KiH mutations in Cε2 domains. C, IgE bispecific with leucine zippers. KiH, knobs-into-holes.
