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. 2022 Jun 16;298(8):102153. doi: 10.1016/j.jbc.2022.102153

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© 2022 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Flow cytometry evaluation of antigen-binding properties of bispecific IgE antibodies. Single-arm binding to CHO/mEGFR, CHO/mPSMA, and CHO.K1 cells in a dose-dependent manner represented by (A) MFI values and (B) percentage of positive cells. Each data point is the mean ± SD of duplicates. C, bsAbs-induced cellular clustering by simultaneous binding to CHO/mEGFR and CHO/mPSMA cells. Pooled data from two independent experiments performed in duplicates are shown. Statistical significance was determined with two-way ANOVA with Dunnett’s multiple comparison test (∗∗∗p < 0.0001, ∗∗p = 0.002, ∗p = 0.04). CHO, Chinese hamster ovary; MFI, mean fluorescence intensity; PSMA, prostate-specific membrane antigen.