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. 2022 Jul 14;3(3):101455. doi: 10.1016/j.xpro.2022.101455

Figure 2.

Figure 2

Xenopus animal cap cells showing that microinjection of 2 pg xWnt8 mRNA at the 2–4 cell stage greatly stabilizes CD63 lysosomes

(A–A‴) Control animal cap injected with DNA encoding membrane GFP and the MVB marker CD63; uninjected cells serve as an internal control.

(B–B‴). Co-injection of xWnt8 mRNA results in a striking stabilization of CD63, a marker of the intraluminal vesicles presents in multivesicular bodies and lysosomes. Canonical Wnt is a potent regulator of lysosome function. The images on the right panels show the merged red, green, blue and visible light channels. Scale bar, 10 μm.