Figure 3.

Xenopus animal cells display lysosomes and macropinocytosis activation after LiCl treatment, which mimics Wnt signaling by inhibiting GSK3 inhibition

(A and A′) Control cells treated with SiR-Lysosome.

(B and B′) LiCl treatment increases active lysosomes. Mimicking Wnt signaling with LiCl shows that lysosomes become more active.

(C and C′) Untreated cells show low uptake of the macropinocytosis marker TMR-Dextran 70 kDa.

(D and D′) LiCl treatment increases macropinocytosis (arrowhead). Scale bar, 10 μm.