Figure 5.

The cognitive impairment of UCCAO mice has been improved after orally administration with compound 15 at the doses of 2.5 mg/kg and 5.0 mg/kg. (A) Escape latency time of mice (s). (B) Site crossings (min⁻¹). (C) Time in the target quadrant (%). (D) cAMP levels of the right brain in mouse (pmol/g). (E) Image is representative trajectories from each group. (F) Representative images of each group with hematoxylin and eosin straining in hippocampal CA3 region (HE, × 200). Donepezil at a dose of 1.0 mg/kg was probed as a positive control. Scale bar: 100 μm. Data are represented as mean values ± SEM (n = 8–12 in each group). ^#P < 0.05 vs control; ^##P < 0.01 vs control; ^###P < 0.001 vs control; ∗P < 0.05 vs model; ∗∗P < 0.01 vs model; ∗∗∗P < 0.001 vs model; ∗∗∗∗P < 0.0001 vs model, respectively.