Table 2.
Selectivity index of 15 against PDE subtypes.
| PDE subtype |
15 |
3a |
||
|---|---|---|---|---|
| IC50 (nmol/L)a | Selectivity index | IC50 (nmol/L)b | Selectivity index | |
| PDE8A1 (480–820) | 11 ± 1 | / | 10 ± 1 | / |
| PDE1C (147–531) | 6179 ± 429 | 562 | 3095 ± 495 | 310 |
| PDE2A (580–919) | 4315 ± 171 | 392 | 2177 ± 104 | 218 |
| PDE3A (679–1087) | >10,000 | >909 | >10,000 | >1000 |
| PDE4D2 (86–413) | 5485 ± 486 | 499 | 7148 ± 340 | 715 |
| PDE5A1 (535–860) | 4835 ± 353 | 440 | >10,000 | >1000 |
| PDE7A1 (130–482) | 4853 ± 359 | 441 | >10,000 | >1000 |
| PDE9A2 (181–506) | >10,000 | >909 | >10,000 | >1000 |
| PDE10A (449–770) | 1224 ± 28 | 111 | 4436 ± 160 | 444 |
a
Data are given as mean ± SD (n ≥ 3).
b
Data reported from our previous report17. except the data of PDE1C, which was determined in this research.