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Pharmacokinetic profiles of 15 in SD rats.
| Parameters | p.o. (5.0 mg/kg) | i.v. (2.5 mg/kg) |
|---|---|---|
| t1/2 (h) | 7.92 ± 0.50 | 5.37 ± 0.86 |
| Tmax (h) | 6.67 ± 2.31 | |
| Cmax (ng/mL) | 1560 ± 223 | |
| AUC(0–t) (h·ng/mL) | 20,544 ± 2779 | 10,142 ± 635 |
| AUC(0–∞) (h·ng/mL) | 23,665 ± 2970 | 10,611 ± 852 |
| MRT(0–t) (h) | 13.4 ± 0.4 | 7.81 ± 1.18 |
| F (%) | 100 |
