Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Drug-like profiles of 15.
| Parameter | Value |
|---|---|
| clogPa | 3.4 |
| tPSAa | 84 |
| Solubility (pH 7.3)b | 4 μg/mL |
| Human plasma protein binding | 97.6% |
| Unbound brain concentrationc | 114 ng/g |
| Cytochrome P450 inhibition (IC50) | |
| CYP2C19 | 19 μmol/L |
| CYP2C9, 2D6, 1A2 | >25 μmol/L |
| CYP3A4-M, 3A4-T | >50 μmol/L |
| hERG inhibition (IC50) | >40 μmol/L |
| Acute toxicity | >1.5 g/kg |
cLogP and tPSA were predicted by Discovery Studio.
The solubility was tested by HPLC.
After an oral dose of 5.0 mg/kg at 4 h in C57BL/6J mice.
