Table 2.
Ligand of POI and E3 ubiquitin ligase for peptide PROTACs.
| POI or E3ligase | Sequence | Ref. | |
|---|---|---|---|
| POI | ER |
![]()
|
57,58 |
| Akt | ![]() |
59 | |
| CREPT | VRALKQKYEELKKEKESLVDK | 60 | |
| Tau | YQQYQDATADEQG | 61,62 | |
| α-Synclein | GVLYVGSKTR | 63,64 | |
| β-Catenin | 65 | ||
| PI3K | GPGGDYAAMGACPASEQGYEEMRA | 66 | |
| FRS2α | IENPQYFSDA | 66 | |
| X-protein | LCLRPVGAESRGRPVSGPFG | 67 | |
| E3 ligase | VHL | ALAPYIP LAP(OH)YI |
57,67,68 |
| Keap1 | LDPETGEYL | 61,69 | |
| SCFβ-TRCP | DRHDS(p)GLDS(p)M | 10 |

