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. 2022 Feb 26;12(7):2990–3005. doi: 10.1016/j.apsb.2022.02.022

Table 2.

Ligand of POI and E3 ubiquitin ligase for peptide PROTACs.

POI or E3ligase Sequence Ref.
POI ER Image 1Image 2 57,58
Akt Image 3 59
CREPT VRALKQKYEELKKEKESLVDK 60
Tau YQQYQDATADEQG 61,62
α-Synclein GVLYVGSKTR 63,64
β-Catenin Image 4 65
PI3K GPGGDYAAMGACPASEQGYEEMRA 66
FRS2α IENPQYFSDA 66
X-protein LCLRPVGAESRGRPVSGPFG 67
E3 ligase VHL ALAPYIP
LAP(OH)YI
57,67,68
Keap1 LDPETGEYL 61,69
SCFβ-TRCP DRHDS(p)GLDS(p)M 10