Table 4.
Other non-small molecule protein degraders.
| Name | Target | Target type | Applied macromolecules | Degradation pathway | Ref. |
|---|---|---|---|---|---|
| Bispecific aptamer chimeras | PTK-7/Met | Membrane protein | Nucleic acid (aptamer) | Lysosome | 156 |
| F-box/intrabody-targeted protein degradation | RHOB-GTP | Intracellular protein | Antibody (nonobody) | Proteasome | 157 |
| M6Pn-LYTACs | ApoE4/EGFR/CD71/PD-L1 | Extracellular/membrane protein | Glycopeptide/antibody | Lysosome | 158 |
| GalNAc-LYTACs | EGFR/integrins/α-DNP antibody/MIF/NeutrAvidin | Extracellular/membrane protein | Tri-GalNAc/peptide/antibody | Lysosome | 159, 160, 161 |
| Sweeping antibodies | IL-6R/C5 | Free antigen | Antibody | Lysosome | 162,163 |
| Abdegs or Seldegs | IgG/trastuzumab | Antibody | Antigen | Lysosome | 164,165 |