Table 1.
Data was obtained from LincSNP 3.0: a database for functional variant of LncRNA at http://bio-bigdata.hrbmu.edu.cn/lincsnp/index.jsp.
| HOTAIR Variant | Regulation | LncRNA Target | Cancers | Functional role | Pubmed ID |
|---|---|---|---|---|---|
| rs920778 | Up regulation | HER2 | gastric | Associated with HOTAIR up regulation, leading to GC susceptibility | 25640751 |
| rs12826786 | Up regulation | – | gastric | No considerable role in susceptibility to GC | 28342055 |
| rs12826786 | Up regulation | – | gastric cardia adenocarcinoma | may be capable of increasing HOTAIR levels | 25476857 |
| rs920778 | Up regulation | – | esophageal squamous cell carcinoma (ESCC) | conferring ESCC susceptibility | 24788237 |
| rs4759314 | Up regulation | – | pancreatic | PVT1 rs1561927 polymorphism the G allele was highly seen in ductal adenocarcinoma and pancreatic neuroendocrine tumor, HOTAIR rs4759314 G allele in pancreatic neuroendocrine tumor, serve as markers in cancer prediction | 30475759 |
| rs4759314 and rs200349340 | Up regulation | pancreatic | minor alleles of rs4759314 and rs200349340 were associated with increased expression of HOTAIR | 30867650 | |
| rs920778 | NA | – | hepatocellular carcinoma | maker for predicting Cancer | 29141248 |
| rs1899663 | Up regulation | – | lung | associated with higher risk of cancer | 30154526 |
| rs4759314 | – | – | lung | rs4759314 and rs12826786 are linked to cancer susceptibility in Chinese Han population | 30464618 |
| rs7958904 | – | – | lung | Platinum chemotherapy response | 26729200 |
| rs920778 | Up regulation | – | lung cancer | rs920778, rs1899663, and rs4759314 are associated with higher risk | 30154526 |
| rs1899663 | – | – | lung | Correlation with platinum chemotherapy response | 26729200 |
| rs12826786 | – | – | breast | genetic susceptibility to cancer and poor prognosis | 26577852 |
| rs920778 | – | – | breast | increased the risk of cancer | 25586347 |
| rs920778 | – | – | breast | increased the risk of cancer | 26547792 |
| rs12826786 | – | – | prostate | Risk of cancer and progression-free survival | 29436234 |
| rs12826786 | – | – | prostate | HOTAIR variants are related to prostate cancer and hyperplasia in an Iranian population | 28259691 |
| rs920778 | – | – | prostate | rs920778 and rs12826786 was not linked to cancer susceptibility | 29436234 |
| rs1899663 | – | – | prostate | rs1899663 T allele increased risk of disease | 28259691 |
| rs920778 | Up regulation | – | ovarian | rs920778 polymorphism was associated with susceptibility to cancer and prognosis | 27690631 |
| rs2366152 | Down regulation | miR-22 | cervical | Involved in pathogenesis of CaCx, miR-22 was capable of decreasing rs2366152C- HOTAIR lncRNA in CaCx cell, acts as a marker for singling out CaCx | 27683269 |
| rs920778 | Up regulation | – | cervical | is able to regulate HOTAIR expression, is associated with susceptibility to cancer | 27467165 |
| rs7958904 | Up regulation | cervical | Linked to cell proliferation and risk of cervical cancer; rs7958904 CC genotype showed increased HOTAIR level than those with GG genotype | 28600545 | |
| rs920778 | Up regulation | – | papillary thyroid carcinoma (PTC) | rs920778 SNP was capable of regulating HOTAIR expression, served as functional genetic variant in PTC | 27549736 |
| rs4759314 | Up regulation | HOXC | urothelial cell carcinoma | Patients are at risk disease after controlling for age and tobacco use and poor overall survival | 30982978 |