Table 2.
MiRNA targeting of HOTAIR through direct and indirect interactions and HOTAIR involving in ceRNA regulatory network.
| HOTAIR involved in direct interaction | ||||
|---|---|---|---|---|
| miRNA | mRNA targets of miRNA | HOTAIR role | Cancer type | PMID |
| miR-1 | FOXC1-activated driver of malignancy, | Hepatocellular carcinoma | 27895772 | |
| miR-130a | a c-Myc activated driver of tumorogenesis | Gallbladder cancer | 24953832 | |
| miR-148a | human leukocyte antigen-G (HLA-G) | Oncogenesis: promoted proliferation, migration and invasion | Cervical cancer | 27574106 |
| miR-152 | HLA-G | Oncogenesis: tumor escape mechanisms | Gastric cancer | 26187665 |
| miR-34a | Oncogenesis | Prostate cancer | 23936419 | |
| miR-101 | COX-2 | Increased invasion and migration of cells | nasopharyngeal carcinoma | 30314699 |
| miR-217 | ZEB1 | Oncogenesis: osteosarcoma development | osteosarcoma | 30367466 |
| HOTAIR involved in indirect interaction | ||||
| miR-7 | SETDB1 | Oncogenesis: invasive phenotype of Cancer cells, | Breast cancer stem cells | 25070049 |
| miR34a | H3K27me3 | Oncogenesis: EMT and metastasis | Gastric cancer | 26136075 |
| miR-125a-5p | CASP2 | Oncogenesis: inhibition of apoptosis, cancer cell survival | Colon cancer | 26962687 |
| HOTAIR involved in ceRNA regulatory network | ||||
| miR-326 | FGF1 | malignant behaviors of cells | Glioma | 26183397 |
| miR-331–3p | HER2 | Oncogenesis | Gastric cancer | 24775712 |
| miR-141 | SKA2 | Oncogenesis: proliferation, migration and invasion | Glioma | 27121316 |