Figure 6.

Proposed model of RGS12 regulation of inflammation via enhancing the ubiquitination. Under inflammatory conditions such as OA, RGS12 promotes the degradation of IκB through enhancing the ubiquitination whereas the process can be inhibited by MG132. Moreover, the increased ubiquitination further degrades the MTAP protein, which can indirectly activate the phosphorylation of IκB. Finally, due to the degradation of IκB, the NF-κB translocates into the nucleus and further promotes the gene expression of cytokines such as IL1β, IL6, and TNFα during inflammation.