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. 2022 Jun 17;298(8):102161. doi: 10.1016/j.jbc.2022.102161

Figure 12.

Figure 12

Analysis of alignment of the amino acid sequences in TMD3 and TMD6 of the SLC19A3s and SLC19A2s of selected animal species.A, the amino acid sequences in the TMD3 and TMD6 of human SLC19A3 were aligned with those in the SLC19A3s of selected animal species using ClustalW program and visualized using BOXSHADE program. The amino acid residues required for the pyridoxine transport function are marked in red. Conservatively different amino acid residues are indicated by shading. B, the amino acid sequence in the TMD3 and TMD6 of human SLC19A2 was similarly aligned with those of the SLC19A2s of selected animal species. SLC19A, solute carrier SLC19A; TMD, transmembrane domain.