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. 2022 Jun 17;298(8):102161. doi: 10.1016/j.jbc.2022.102161

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© 2022 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Predicted structure of hSLC19A3. The structures of hSLC19A3 (A) and mSlc19a3 (B) from AlphaFold Protein Structure Database (17) were visualized from the horizontal and extracellular sides with PyMol program to highlight TMD3 (red) and TMD6 (blue). The positions of the critical residues needed for the pyridoxine transport function (⁸⁶Gln, ⁸⁷Gly, ⁹¹Ile, ⁹³Thr, and ⁹⁴Trp in TMD3 and ¹⁶⁸Ser and ¹⁷³Asn in TMD6) in hSLC19A3 and their counterparts in mSlc19a3 are indicated. hSLC19A3, human solute carrier SLC19A3; mSlc19a3, mouse Slc19a3; TMD, transmembrane domain.