Table 2.

Impulsive system: resting-state functional connectivity with the seed region “right nucleus accumbens” after 18 mg nalmefene compared to placebo

Side	Brain areas	Size	MNI coordinates			tmax	Cluster pFDR	Peak p-unc
			x	y	z
L	Putamen, pallidum, caudate	578	− 20	00	14	− 5.22	0.0004	< 0.0001
L	Insula
	Thalamus Claustrum
R	Putamen, pallidum	460	26	04	− 10	− 5.39	0.0011	< 0.0001
R	Thalamus
R	Amygdala

Second level SCA results: resting-state functional connectivity between the seed region right Nucleus accumbens and the rest of the brain after 18 mg nalmefene compared to placebo (contrast: nalmefene > placebo). Combined voxel-wise-threshold (p < 0.01) and cluster-extent threshold k > 460 Voxel, corresponding to pFDR < 0.05; MNI, Montreal Neurological Institute.