Table 3.

Reflective system: resting-state functional connectivity with the seed region “left orbitofrontal cortex” after 18 mg nalmefene compared to placebo

Side	Lobe	Brain areas	Size	MNI coordinates			tmax	Cluster pFDR	Peak p-unc
				x	y	z
L		Insula	1208	− 50	06	20	− 5.84	< 0.0001	< 0.0001
L	Frontal	Inferior frontal gyrus, precentral gyrus, rolandic operculum
L	Temporal	Superior temporal gyrus, middle temporal gyrus
R		Posterior cingulate gyrus, parahippocampal gyrus	569	18	− 64	20	5.58	0.0005	< 0.0001
R	Parietal	Precuneus
	Occipital	Cuneus, lingual gyrus, calcarine
R		Insula	548	44	06	02	− 6.59	0.0005	< 0.0001
R		Putamen, pallidum Claustrum
R	Frontal	Inferior frontal gyrus, precentral gyrus, rolandic operculum
	Temporal	Superior temporal gyrus
		Posterior cingulate gyrus	503	− 14	− 62	20	5.67	0.0007	< 0.0001
L	Parietal	Precuneus, superior parietal lobule, inferior parietal lobule
L	Occipital	Cuneus, superior occipital gyrus, middle occipital gyrus, calcarine
R	Parietal	Precuneus, angular gyrus, inferior parietal lobule, superior parietal lobule, supramarginal gyrus	442	50	− 44	48	5.36	0.0015	< 0.0001
R	Occipital	Cuneus, superior occipital gyrus, middle occipital gyrus

Second level SCA results: resting-state functional connectivity between the seed region left orbitofrontal cortex and the rest of the brain after 18 mg nalmefene compared to placebo (contrast: nalmefene > placebo). Combined voxel-wise-threshold (p < 0.01) and cluster-extent threshold k > 442 Voxel, corresponding to pFDR < 0.05; MNI, Montreal Neurological Institute.