Table 4.

Salience network: resting-state functional connectivity with the seed region “left insular cortex” after 18 mg nalmefene compared to placebo

Side	Lobe	Brain areas	Size	MNI coordinates			tmax	Cluster pFDR	Peak p-unc
				x	y	z
L		Anterior cingulate, dorsal anterior cingulate cortex	388	− 12	50	00	− 5.22	0.0198	< 0.0001
L|R	Frontal	Medial frontal gyrus, superior frontal gyrus, anterior prefrontal cortex

Second level SCA results: resting-state functional connectivity between the seed region left insular cortex and the rest of the brain after 18 mg nalmefene compared to placebo (contrast: nalmefene > placebo). Combined voxel-wise-threshold (p < 0.01) and cluster-extent threshold k > 388 Voxel, corresponding to pFDR < 0.05; MNI, Montreal Neurological Institute.