Table 5.

Salience network: resting-state functional connectivity with the seed region “anterior cingulate cortex” after 18 mg nalmefene compared to placebo

Side	Lobe	Brain areas	Size	MNI coordinates			tmax	Cluster pFDR	Peak p-unc
				x	y	z
R	Parietal	Angular gyrus	372	42	− 56	20	5.76	0.0205	< 0.0001
R	Temporal	Middle temporal gyrus, superior temporal gyrus, inferior temporal gyrus, parahippocampal gyrus (9 V)

Second level SCA results: resting-state functional connectivity between the seed region anterior cingulate cortex and the rest of the brain after 18 mg nalmefene compared to placebo (contrast: nalmefene > placebo). Combined voxel-wise-threshold (p < 0.01) and cluster-extent threshold k > 372 Voxel, corresponding to pFDR < 0.05; MNI, Montreal Neurological Institute.