Table 6.

Default mode network: resting-state functional connectivity with the seed region “medial prefrontal cortex” after 18 mg nalmefene compared to placebo

Side	Lobe	Brain areas	Size	MNI coordinates			tmax	Cluster pFDR	Peak p-unc
				x	y	z
R		Insula	369	50	00	10	− 4.82	0.0127	0.0002
R	Frontal	Inferior frontal gyrus (pars opercularis, triangularis, orbitalis), precentral gyrus, rolandic operculum

Second level SCA results: resting-state functional connectivity between medial prefrontal cortex and the rest of the brain after 18 mg nalmefene compared to placebo (contrast: nalmefene > placebo). Combined voxel-wise-threshold (p < 0.01) and cluster-extent threshold k > 369 Voxel, corresponding to pFDR < 0.05; MNI, Montreal Neurological Institute.