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. 2022 Apr 25;239(8):2559–2571. doi: 10.1007/s00213-022-06144-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visithttp://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Mean and standard deviation of the relative expression of the genes coding several activators of the mTOR network studied, normalised to saline/withdrawal 1 (VhSA) values. The rats of the groups that self-administered heroin showed higher mRNA levels of Igf1r (F_1,28 = 4.931, p = 0.035, η2 = 0.147), Igf2r (F_1,28 = 6.277, p = 0.018, η2 = 0.161), Akt2 (F_1,28 = 5.763, p = 0.023, η2 = 0.158) and Gsk3a (F_1,28 = 5.556, p = 0.025, η2 = 0.162). ^#Significant effect of the treatment factor (p < 0.05)