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. 2022 Apr 25;239(8):2559–2571. doi: 10.1007/s00213-022-06144-2

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© The Author(s) 2022

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Fig. 6 — Mean and standard deviation of the relative expression of the genes coding for the same of the proteins that constitute the mTOR complexes, normalised to Saline/Withdrawal 1 (VhSA) values. The rats that self-administered heroin showed higher mRNA levels of Rictor than their saline-treated controls after 1 day of withdrawal (F_1,28 = 5.094, p = 0.032, η2 = 0.182). Also, among the groups that self-administered saline solution, the rats that underwent 30 days of withdrawal showed higher Rictor mRNA levels than the rats that only had one day of withdrawal (F_1,28 = 7.104, p = 0.013, η2 = 0.254). *Significant effect of the simple effect analyses (p < 0.05)