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. 2022 Mar 14;269(8):4270–4280. doi: 10.1007/s00415-022-11055-5

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© The Author(s) 2022, corrected publication 2022

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Fig. 2 — Correlation between plasma NfL levels, age at baseline, and age at onset of cognitive disturbs in SCD, MCI, and AD patients. Scatter plots with lines of best fit (95% CI) show the relationship between plasma NfL levels and age at baseline (A) and age at onset (B). NfL levels were significantly correlated with age at baseline and age at onset in SCD (Spearman’s ρ 0.529, p = 0.001 and Spearman’s ρ 0.364, p = 0.040, respectively) and MCI (Spearman’s ρ 0.550, p < 0.001 and Spearman’s ρ 0.416, p = 0.004, respectively) groups but not in AD