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. 2022 Jul 18;79(8):429. doi: 10.1007/s00018-022-04424-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Integration of stimulation specific H3K27ac enhancers with global gene expression data in cDC1. A Heatmap showing odds ratio of association of CpG, pIC specific or common CpG-pIC genes with genes annotated to CpG and pIC specific enhancer. B Boxplot showing the scaled vst comparison of H3K27ac ChIP enrichment on CpG, pIC and common CpG-pIC specific genes identified in Fig. 1B. C Scatter plots depicting the correlation of gene expression and H3K27ac enhancer activity in CpG, pIC and CpG + pIC stimulated condition. The CpG, pIC specific and common CpG-pIC genes are highlighted in blue, red and green color respectively and selected representative genes from respective clusters are marked in the plots. D IGV browser snapshot representing RNA-seq and H3K27ac enrichment in unstimulated, CpG, pIC and combined CpG + pIC on Il12b, Il6, Il10 and Ifnb1 gene loci. E Scatter plots showing the Super Enhancers identified at 2 h and 6 h (CpG, pIC) stimulated cDC1. The CpG/pIC specific genes annotated to the Super Enhancer regions have been marked for each condition