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. 2022 Mar 2;269(8):4161–4173. doi: 10.1007/s00415-022-11029-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Workflow and methodology used in this study. b Principal component analysis of gene expression results showing the pairwise comparison between different groups: IBM, TMD and Amputees. c IBM-specific differentially expressed genes were determined by comparing IBM cases with amputee and TMD groups. d Comparison between IBM-specific differentially expressed genes (cyan) and IBM-specific differentially spliced genes (magenta)