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. 2022 Mar 2;269(8):4161–4173. doi: 10.1007/s00415-022-11029-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Statistical over-representation tests were performed on a list of differentially spliced RNAs, using clusterProfiler for a Biological Processes, b Cellular component, and c Molecular function. d An UpSet plot is shown comparing six different sets, namely, IBM-specific differentially spliced (1271 genes), mobilization of Ca²⁺ (80 genes), calcium-induced T lymphocyte apoptosis (69 genes), the flux of Ca²⁺ (51 genes), quantity of Ca²⁺ (51 genes), and release of Ca²⁺ (33 genes). Dots and lines represent subsets of different lists. The horizontal bar graph (wine color) represents the size of each set, while the vertical histogram (black) represents the number of RNAs in each subset. The 10 RNAs that are both differentially expressed and differentially spliced are shown with a red circle with their gene names (black)