Table 1.
Top 10 dysregulated canonical pathways identified by IPA. The significance of the identified pathway is shown with a p value and the number of differentially expressed genes observed in the IBM-specific dataset compared to the number of genes present in the database for each pathway
| Ingenuity canonical pathways | p value | Number of genes in dataset/number of genes in database |
|---|---|---|
| Dendritic cell maturation | 5.72E–31 | 106/357 |
| T-cell receptor signaling | 2.30E–25 | 97/355 |
| T-cell exhaustion signaling pathway | 3.12E–25 | 94/338 |
| Cdc42 signaling | 7.63E–24 | 88/315 |
| iCOS-iCOSL signaling in T helper cells | 4.10E–23 | 81/280 |
| CD28 signaling in T helper cells | 1.13E–22 | 82/290 |
| OX40 signaling pathway | 4.03E–21 | 68/222 |
| Calcium-induced T lymphocyte apoptosis | 1.29E–20 | 69/232 |
| Nur77 signaling in T lymphocytes | 3.07E–20 | 72/253 |
| Role of NFAT in regulation of the immune response | 4.57E–19 | 87/360 |