Table 2.
Lymphocyte subsets in healthy controls and patients. Cell counts are given as median value/ µl (interquartile range). P values are given for univariate analysis between total group of cancer patients and healthy controls
| Healthy controls Median cell count (interquartile range) (n = 50) |
Colon carcinoma patients Median cell count (interquartile range) (n = 47) |
p value univariate analysis | |
|---|---|---|---|
| Total lymphocytes | 1878 (1282−2292) | 1320 (1046−1666) | 0.000 |
| CD3 + cells | 1175 (806−1678) | 868 (714−1190) | 0.011 |
| CD8 + cells | 292 (203−493) | 229 (131−344) | 0.009 |
| Naive | 82 (35−140) | 36 (16−67) | 0.004 |
| Memory | 118 (63−165) | 82 (45−118) | 0.008 |
| CM | 29 (13−55) | 23 (13−50) | 0.563 |
| EM | 94 (55−143) | 76 (45−112) | 0.196 |
| EMRA | 51 (22−128) | 45 (17−114) | 0.623 |
| Early | 180 (130−295) | 119 (58−169) | 0.000 |
| Intermediate | 21 (12−34) | 11 (6−26) | 0.006 |
| Late | 51 (26−124) | 58 (19−150) | 0.931 |
| Exhausted | 86 (54−136) | 54 (29−89) | 0.002 |
| Terminal effector | 24 (12−95) | 34 (11−117) | 0.697 |
| Regulatory | 0 (0−1) | 0 (0−1) | 0.277 |
| IL2 | 1 (0−1) | 1 (0−2) | 0.328 |
| HLA-DR | 31 (17−61) | 76 (37−141) | 0.000 |
| CD69 | 32 (17−89) | 15 (8−25) | 0.000 |
| CD4 + cells | 765 (525−1017) | 528 (400−768) | 0.001 |
| Naive | 311 (173−416) | 159 (79−295) | 0.002 |
| Memory | 404 (309−590) | 311 (214−378) | 0.000 |
| CM | 269 (157−402) | 190 (124−238) | 0.003 |
| EM | 143 (93−238) | 116 (78−167) | 0.097 |
| EMRA | 4 (1−32) | 5 (2−19) | 0.636 |
| Th1 | 27 (14−58) | 19 (10−40) | 0.156 |
| Th2 | 44 (30−67) | 46 (32−62) | 0.917 |
| Th17 | 60 (35−82) | 47 (33−67) | 0.081 |
| Regulatory | 43 (29−60) | 28 (19−43) | 0.002 |
| Il2R + | 17 (8−21) | 15 (8−25) | 0.874 |
| HLA-DR | 39 (27−60) | 52 (44−65) | 0.015 |
| CD69 | 12 (7−19) | 13 (9−21) | 0.274 |
| CD3 + CD56 + cells | 45 (18−81) | 43 (19−108) | 0.945 |
| NK cells | 226 (139−300) | 150 (87−223) | 0.002 |
| CD56 + CD16 + | 193 (111−274) | 129 (65−203) | 0.002 |
| CD56dim CD16bright | 15 (11−20) | 9 (7−18) | 0.042 |
| CD56bright CD16dim | 15 (10−19) | 11 (8−14) | 0.002 |
| B cells | 206 (146−276) | 122 (69−185) | 0.000 |
| Naive | 126 (90−172) | 73 (37−113) | 0.000 |
| Non-class-switched Memory | 7 (5−13) | 7 (3−14) | 0.328 |
| Class switched | 24 (14−43) | 16 (8−24) | 0.001 |
| Transitory | 10 (5−18) | 2 (1−4) | 0.000 |
| CD4/CD8 Ratio | 2.4 (1.6–3.3) | 2.2 (1.8−3.3) | 0.997 |
Bold values indicate lymphocyte subsets with significant differences (p < 0.005)