Table 3.

Univariate analysis of age-dependent lymphocyte changes per ten years for the entire cohort (n = 97). Cell counts are given as median value/µl (interquartile range)

	Median Cell count/µl (interquartile range)	Relative Cell count deviation per 10 years	p value
Total lymphocytes	1546.4 (1176.0–2055.7)	− 7.2	0.000
CD3 + cells	1047.5 (756.8–1497.3)	− 6.9%	0.003
CD8 + cells	252.3 (182.3–423.3)	− 13.3%	0.000
Naive	56.1 (20.0–107.4)	− 33.4%	0.000
Memory	96.3 (51.2–143.9)	− 12.4%	0.009
CM	25.8 (13.6–52.7)	− 10.6%	0.069
EM	79.2 (48.5–135.0)	− 7.0%	0.110
EMRA	50.6 (18.2–115.6)	2.4%	0.714
early	159.5 (79.1–216.3)	− 20.9%	0.000
Intermediate	15.0 (8.2–30.3)	− 10.4%	0.028
Late	54.1 (23.5–124.5)	− 3.6%	0.553
Exhausted	69.5 (41.8–113.8)	− 7.9%	0.039
Terminal effector	29.0 (11.6–97.6)	0.09%	0.990
HLADR +	43.2 (22.0–92.4)	11.2%	0.101
CD69 +	19.8 (11.4–53.6)	− 25.6%	0.000
Regulatory	0.3 (0.2–0.6)	− 4.8%	0.593
Il2R +	0.6 (0.3–1.5)	17.0%	0.035
CD4 + cells	624.1 (454.7–898.8)	− 8.4%	0.003
Naive	226.8 (130.0–372.6)	− 14.8	0.000
Memory	340.1 (245.4–466.6)	− 8.4%	0.006
CM	220.2 (143.1–290.4)	− 10.9%	0.001
EM	123.9 (87.9–200.8)	− 1.3%	0.724
EMRA	3.8 (1.4–24.6)	22.3%	0.039
HLADR +	47.2 (32.4–63.0)	8.2%	0.018
CD69 +	12.6 (7.6–18.9)	3.3%	0.535
Th1	21.7 (12.4–48.1)	− 1.1%	0.838
Th2	44.8 (31.0–62.5)	4.2%	0.261
Th17	50.7 (34.2–75.1)	− 3.3%	0.387
Regulatory	35.6 (24.0–51.7)	− 6.8%	0.033
Il2R +	15.1 (8.4–21.7)	− 4.7%	0.225
CD3 + CD56 + cells	44.2 (19.0–83.2)	3.8%	0.548
NK cells	182.8 (107.8–264.8)	− 6.7%	0.038
CD56 + CD16 +	152.9 (90.1–238.1)	− 6.8%	0.008
CD56dim CD16bright	13.1 (8.0–19.7)	− 5.1%	0.156
CD56bright CD16dim	12.2 (9.3–17.2)	− 6.6%	0.064
B cells	162.2 (100.8–234.0)	− 16.7%	0.000
Naive	99.1 (60.1–158.9)	− 19.4%	0.000
Memory non-class switch	7.2 (3.7–13.2)	− 14.8%	0.003
Memory class switch	19.1 (9.8–31.2)	− 12.0%	0.009
Transitional	4.5 (1.6–10.2)	− 38.4%	0.000

Bold values indicate lymphocyte subsets with significant differences (p < 0.005)